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首页> 外文期刊>Biomaterials >TPGS-stabilized NaYbF4:Er upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance
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TPGS-stabilized NaYbF4:Er upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance

机译：TPGS稳定的NaYbF4：Er上转换纳米颗粒，用于双模式荧光/ CT成像和抗癌药物递送，以克服多药耐药性

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摘要

Multi-drug resistance (MDR) is a major cause of failure in cancer chemotherapy. Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been extensively investigated for overcoming MDR in cancer therapy because of its ability to inhibit P-glycoprotein (P-gp). In this work, TPGS was for the first time used as a new surface modifier to functionalize NaYbE4:Er upconversion nanoparticles (UNCPs) and endowed the as-prepared products (TPGS-UCNPs) with excellent water-solubility, P-gp inhibition capability and imaging-guided drug delivery property. After the chemotherapeutic drug (doxorubicin, DOX) loading, the as-formed composites (TPGS-UCNPs-DOX) exhibited potent killing ability for DOX-resistant MCF-7 cells. Flow-cytometric assessment and Western blot assay showed that the TPGS-UCNPs could potently decrease the P-gp expression and facilitate the intracellular drug accumulation, thus achieving MDR reversal. Moreover, considering that UCNPs process efficient upconversion emission and Yb element contained in UCNPs has strong X-ray attenuation ability, the as-obtained composite could also serve as a dual-modal probe for upconversion luminescence (UCL) imaging and X-ray computed tomography (CT) imaging, making them promising for imaging-guided cancer therapy. (C) 2014 Elsevier Ltd. All rights reserved.
机译：多药耐药性（MDR）是癌症化疗失败的主要原因。生育酚聚乙二醇1000琥珀酸酯（TPGS）因其抑制P-糖蛋白（P-gp）的能力而被广泛研究用于克服癌症治疗中的MDR。在这项工作中，TPGS首次用作新的表面改性剂，以功能化NaYbE4：Er上转换纳米颗粒（UNCP），并赋予已制备的产品（TPGS-UCNPs）优异的水溶性，P-gp抑制能力和成像引导的药物递送特性。加载化疗药物（阿霉素，DOX）后，形成的复合物（TPGS-UCNPs-DOX）显示出对DOX耐药MCF-7细胞的有效杀伤能力。流式细胞仪和Western blot检测结果表明，TPGS-UCNPs可以有效降低P-gp的表达，促进细胞内药物的积累，从而逆转MDR。此外，考虑到UCNP处理有效的上转换发射并且UCNP中包含的Yb元素具有很强的X射线衰减能力，因此，所获得的复合材料还可以用作上转换发光（UCL）成像和X射线计算机断层摄影的双模探针。 （CT）成像，使其有希望用于成像指导的癌症治疗。 （C）2014 Elsevier Ltd.保留所有权利。

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