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Conductive PPY/PDLLA conduit for peripheral nerve regeneration

机译：导电PPY / PDLLA导管用于周围神经再生

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摘要

The significant drawbacks and lack of success associated with current methods to treat critically sized nerve defects have led to increased interest in neural tissue engineering. Conducting polymers show great promise due to their electrical properties, and in the case of polypyrrole (PPY), its cell compatibility as well. Thus, the goal of this study is to synthesize a conducting composite nerve conduit with PPY and poly(d, l-lactic acid) (PDLLA), assess its ability to support the differentiation of rat pheochromocytoma 12 (PC12) cells invitro, and determine its ability to promote nerve regeneration invivo. Different amounts of PPY (5%, 10%, and 15%) are used to synthesize the conduits resulting in different conductivities (5.65, 10.40, and 15.56ms/cm, respectively). When PC12 cells are seeded on these conduits and stimulated with 100mV for 2h, there is a marked increase in both the percentage of neurite-bearing cells and the median neurite length as the content of PPY increased. More importantly, when the PPY/PDLLA nerve conduit was used to repair a rat sciatic nerve defect it performed similarly to the gold standard autologous graft. These promising results illustrate the potential that this PPY/PDLLA conducting composite conduit has for neural tissue engineering.
机译：与当前的治疗临界尺寸神经缺损的方法相关的重大缺陷和缺乏成功导致人们对神经组织工程的兴趣增加。导电聚合物由于其电性能而显示出巨大的希望，而在聚吡咯（PPY）的情况下，它的电池兼容性也很好。因此，本研究的目的是合成具有PPY和聚（d，l-乳酸）（PDLLA）的传导性复合神经导管，评估其支持大鼠嗜铬细胞瘤12（PC12）细胞体外分化的能力，并确定其促进神经再生的能力。使用不同量的PPY（5％，10％和15％）来合成导管，从而产生不同的电导率（分别为5.65、10.40和15.56ms / cm）。当将PC12细胞接种在这些导管上并用100mV刺激2h时，随着PPY含量的增加，带有神经突的细胞的百分比和中位神经突的长度都显着增加。更重要的是，当使用PPY / PDLLA神经导管修复大鼠坐骨神经缺损时，其表现类似于金标准自体移植物。这些有希望的结果表明，这种PPY / PDLLA导电复合导管具有用于神经组织工程的潜力。

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