• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases >Oral bacterial community dynamics in paediatric patients with malignancies in relation to chemotherapy-related oral mucositis: A prospective study
【24h】

Oral bacterial community dynamics in paediatric patients with malignancies in relation to chemotherapy-related oral mucositis: A prospective study

机译：儿科恶性肿瘤患者与化疗相关的口腔黏膜炎的口腔细菌群落动态：一项前瞻性研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The role of oral bacteria in the development of chemotherapy-related oral mucositis has not been fully elucidated. This study aimed to investigate oral bacterial community diversity and dynamics in paediatric patients with malignancies in relation to the occurrence of oral mucositis. Patients with malignancies (n = 37) and reference individuals without known systemic disorders (n = 38) were recruited. For patients, oral bacterial samples were taken from mucosal surfaces both at the time of malignancy diagnosis and during chemotherapy. If oral mucositis occurred, samples were taken from the surface of the mucositis lesions. Oral mucosal bacterial samples were also taken from reference individuals. All samples were assessed using a 16S ribosomal RNA gene 454 pyrosequencing method. A lower microbial diversity (p < 0.01) and a higher intersubject variability (p < 0.001) were found in patients as compared with reference individuals. At the time of malignancy diagnosis (i.e. before chemotherapy) patients that later developed mucositis showed a higher microbial diversity (p < 0.05) and a higher intersubject variability (p < 0.001) compared with those without mucositis. The change of bacterial composition during chemotherapy was more pronounced in patients who later developed mucositis than those without mucositis (p < 0.01). In conclusion, we found a higher microbial diversity at the time of malignancy diagnosis in patients who later develop oral mucositis and that these patients had a more significant modification of the bacterial community by chemotherapy before the occurrence of mucositis. These findings may possibly be of clinical importance in developing better strategies for personalized preventive management.
机译：口腔细菌在与化疗有关的口腔粘膜炎发展中的作用尚未完全阐明。这项研究旨在调查与口腔黏膜炎的发生有关的小儿恶性肿瘤患者口腔细菌群落的多样性和动态。招募了患有恶性肿瘤的患者（n = 37）和无已知系统性疾病的参考个体（n = 38）。对于患者，在恶性诊断时和化疗期间均从粘膜表面获取口腔细菌样品。如果发生口腔粘膜炎，则从粘膜炎病变表面取样。口腔粘膜细菌样品也取自参考个体。使用16S核糖体RNA基因454焦磷酸测序方法评估所有样品。与参考个体相比，患者的微生物多样性较低（p <0.01），受试者间变异性较高（p <0.001）。在诊断为恶性肿瘤时（即在化疗之前），与没有粘膜炎的患者相比，后来发展为粘膜炎的患者表现出更高的微生物多样性（p <0.05）和更高的受试者间变异性（p <0.001）。后来发生粘膜炎的患者比没有粘膜炎的患者在化疗期间细菌组成的变化更为明显（p <0.01）。总而言之，我们发现在后来发展为口腔粘膜炎的患者进行恶性肿瘤诊断时，其微生物多样性更高，并且这些患者在发生粘膜炎之前通过化学疗法对细菌群落具有更显着的修饰。这些发现可能对制定更好的个性化预防管理策略具有重要的临床意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号