Practical and efficient synthesis of pyrano(3,2-c)pyridone, pyrano(4,3-b)pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents.

Fan X; Feng D; Qu

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Practical and efficient synthesis of pyrano(3,2-c)pyridone, pyrano(4,3-b)pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents.

机译：实用有效的方法合成吡喃（3,2-c）吡啶酮，吡喃（4,3-b）吡喃及其与核苷的杂化物，作为潜在的抗病毒药和抗疟药。

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A highly practical and efficient preparation of pyrano[3,2-c]pyridone and pyrano[4,3-b]pyran derivatives was developed via an ionic liquid mediated and promoted multi-component reaction of aldehyde (1), 4-hydroxy-pyridin-2(1H)-one or 4-hydroxy-2-pyranone (2), and malononitrile (3). As an application, a series of pyrimidine nucleoside-pyrano[3,2-c]pyridone or pyrano[4,3-b]pyran hybrids were efficiently obtained. These hybrid compounds were evaluated as potential antiviral and antileishmanial agents and showed encouraging biological activities.

机译：通过离子液体介导和促进的醛（1），4-羟基-吡咯烷酮的多组分反应，开发了一种高度实用和有效的吡喃并[3,2-c]吡啶酮和吡喃并[4,3-b]吡喃衍生物的制备方法吡啶-2（1H）-1或4-羟基-2-吡喃酮（2）和丙二腈（3）。作为应用，有效地获得了一系列嘧啶核苷-吡喃并[3,2-c]吡啶酮或吡喃并[4,3-b]吡喃杂化物。这些杂合化合物被评估为潜在的抗病毒药和抗疟药，并显示出令人鼓舞的生物学活性。

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《Bioorganic and Medicinal Chemistry Letters》 |2010年第3期|共5页
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Fan X; Feng D; Qu;
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1. Practical and efficient synthesis of pyrano(3,2-c)pyridone, pyrano(4,3-b)pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents. [J] . Fan X, Feng D, Qu Bioorganic and Medicinal Chemistry Letters . 2010,第3期

机译：实用有效的方法合成吡喃（3,2-c）吡啶酮，吡喃（4,3-b）吡喃及其与核苷的杂化物，作为潜在的抗病毒药和抗疟药。
2. Fast Efficient and General PASE Approach to Medicinally Relevant 4H,5H-Pyrano-[4,3-b]pyran-5-one and 4,6-Dihydro-5H-pyrano-[3,2-c]pyridine-5-one Scaffolds [J] . Elinson Michail N., Ryzhkov Fedor V., Nasybullin Ruslan F., Helvetica chimica acta . 2016,第9期

机译：与药物相关的4H，5H-吡喃-[4,3-b]吡喃-5-酮和4,6-二氢-5H-吡喃-[3,2-c]吡啶-5-酮的快速有效且通用的PASE方法脚手架
3. A green, efficient, and rapid procedure for the synthesis of pyrano[3,2-c] quinoline and pyrano[3,2-c]pyridone derivatives catalyzed by [BMIm]Cl [J] . Esmayeel Abbaspour-Gilandeh, Seyyedeh Cobra Azimi, Kurosh Rad-Moghadam, Iranian Journal of Catalysis . 2013,第1期

机译：[BMIm] Cl催化合成吡喃并[3,2-c]喹啉和吡喃并[3,2-c]吡啶酮衍生物的绿色，高效，快速方法
4. Design and total synthesis of novel nucleosides as potential antiviral agents. [D] . Zhang, Jianzhong. 1997

机译：设计和全合成新型核苷作为潜在的抗病毒剂。
5. An efficient synthesis of 4H-pyrano quinolinone derivatives catalysed by a versatile organocatalyst tetra-n-butylammonium fluoride and their pharmacological screening [O] . Pratibha Prasad, Pratik G. Shobhashana, Manish P. Patel 2017

机译：多功能有机氟化四正丁基铵催化四氢吡喃醌衍生物的高效合成及其药理筛选
6. General Method for the Preparation of Substituted 2-Amino-4H,5H-pyrano[4,3-b]pyran-5-ones and 2-Amino-4H-pyrano[3,2-c]pyridine-5-ones [O] . Dieter Heber, Ivo C. Ivanov, Edmont V. Stoyanov 2000

机译：制备取代的2-氨基-4H，5H-吡喃并[4,3-b]吡喃-5-酮和2-氨基-4H-吡喃并[3,2-c]吡啶-5-酮的通用方法

Practical and efficient synthesis of pyrano(3,2-c)pyridone, pyrano(4,3-b)pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agents.

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