Synthesis, antimicrobial evaluation and QSAR studies of novel piperidin-4-yl-5-spiro-thiadiazoline derivatives.

Umamatheswari S; Balaji B; Ramanathan M; Kabilan S

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Synthesis, antimicrobial evaluation and QSAR studies of novel piperidin-4-yl-5-spiro-thiadiazoline derivatives.

【24h】

Synthesis, antimicrobial evaluation and QSAR studies of novel piperidin-4-yl-5-spiro-thiadiazoline derivatives.

机译：新的哌啶-4-基-5-螺-噻二唑啉衍生物的合成，抗菌评估和QSAR研究。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In an attempt to find a new class of antimicrobial agents, a series of new 1,3,4-thiadiazolines were synthesized from 2,6-diarylpiperidin-4-ones, via the corresponding 4'-phenylthiosemicarbazones. All the synthesized compounds (23-39) were virtually screened against bacterial (Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi) and fungal strains (Candida albicans, Rhizopus sp, Aspergillus niger and Aspergillus flavus) by serial dilution method. QSAR study indicated that the increase in weakly polar component of solvent accessible surface area will favour antibacterial activity while increase in polarizability and decrease in ionisation potential and hydrogen bond donor will favour antifungal activity.

机译：为了找到一类新的抗微生物剂，通过2，6-二芳基哌啶-4-酮经相应的4′-苯基硫代半咪唑酮合成了一系列新的1，3，4-噻二唑啉。通过系列稀释法对所有合成的化合物（23-39）进行了细菌（金黄色葡萄球菌，大肠杆菌，铜绿假单胞菌和伤寒沙门氏菌）和真菌菌株（白色念珠菌，根霉属，黑曲霉和黄曲霉）的虚拟筛选。 QSAR研究表明，溶剂可及表面积中弱极性组分的增加将有利于抗菌活性，而极化性的增加和电离势的降低以及氢键供体的降低将有利于抗真菌活性。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |2010年第23期|共6页
作者
Umamatheswari S; Balaji B; Ramanathan M; Kabilan S;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Synthesis, antimicrobial evaluation and QSAR studies of novel piperidin-4-yl-5-spiro-thiadiazoline derivatives. [J] . Umamatheswari S, Balaji B, Ramanathan M, Bioorganic and Medicinal Chemistry Letters . 2010,第23期

机译：新的哌啶-4-基-5-螺-噻二唑啉衍生物的合成，抗菌评估和QSAR研究。
2. Synthesis, antimicrobial evaluation, QSAR and in Silico ADMET studies of decanoic acid derivatives. [J] . Kumar A, Singh S, Jain S, Acta Poloniae Pharmaceutica: Durg Research . 2011,第2期

机译：癸酸衍生物的合成，抗菌评估，QSAR和In silico ADMET研究。
3. Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives. [J] . Fassihi A, Abedi D, Saghaie L, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2009,第5期

机译：某些3-羟基吡啶-4-酮和3-羟基吡喃-4-酮衍生物的合成，抗菌评估和QSAR研究。
4. Synthesis, Biological Evaluation and 2D-QSAR Study of Halophenyl Bis-Hydrazones as Antimicrobial and Antitubercular Agents [C] . Sara T.A. Al-Rashood, Hatem A. Abdel Aziz, Wagdy M. Eldehna, PEGS . 2015

机译：卤素双腙作为抗微生物和抗胆糖剂的合成，生物学评价和2D-QSAR研究
5. I. Total synthesis and biological evaluation of reblastatin, autolytimycin and related structural derivatives. II. Synthesis and biological evaluation of stereochemical analogs of bistramide A [D] . Wrona, Iwona Ewa 2009

机译：I.角质素，自身霉素和相关结构衍生物的全合成和生物学评估。二。双链酰胺A的立体化学类似物的合成和生物学评价
6. Synthesis Biological Evaluation and 2D-QSAR Study of Halophenyl Bis-Hydrazones as Antimicrobial and Antitubercular Agents [O] . Hatem A. Abdel-Aziz, Wagdy M. Eldehna, Mohamed Fares, 2015

机译：卤代苯基双-作为抗菌剂和抗结核剂的合成生物学评价和二维QSAR研究
7. Synthesis, fungicidal evaluation and 3D-QSAR studies of novel 1,3,4-thiadiazole xylofuranose derivatives. [O] . Guanghui Zong, Xiaojing Yan, Jiawei Bi, 2017

机译：新型1,3,4-噻二唑木呋喃糖衍生物的合成，杀菌评价和3D-QsaR研究。
8. Study on Synthesis of N-Nitroborazine Compounds. II. Borazine Derivatives. [R] . hirata, t. 1971

机译：N-硝基嗪类化合物的合成研究。 II。 Borazine衍生物。

Synthesis, antimicrobial evaluation and QSAR studies of novel piperidin-4-yl-5-spiro-thiadiazoline derivatives.

摘要

著录项

相似文献

相关主题

期刊订阅