N-substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators.

Thewlis KM; Aldegheri L; Harries MH; Mookherjee C; Oliosi B; Ward SE

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N-substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators.

机译：N-取代的吡咯烷和四氢呋喃作为新型AMPAR正调节剂。

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A series of novel AMPA receptor positive modulators displaying CNS penetration have been discovered with sub-micromolar activity and good selectivity over the cardiac channel receptor, hERG. We describe here the synthesis of these compounds which are biaryl pyrrolidine and tetrahydrofuran sulfonamides and disclose their activities against the human GluA2 flip isoform homotetrameric receptor.

机译：已发现一系列显示CNS渗透的新型AMPA受体阳性调节剂，具有亚微摩尔活性，并且对心脏通道受体hERG具有良好的选择性。我们在这里描述了这些化合物的合成，它们是联芳基吡咯烷和四氢呋喃磺酰胺，并公开了它们对人GluA2翻转异构体同四聚体受体的活性。

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《Bioorganic and Medicinal Chemistry Letters》 |2010年第23期|共4页
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Thewlis KM; Aldegheri L; Harries MH; Mookherjee C; Oliosi B; Ward SE;
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1. N-substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators. [J] . Thewlis KM, Aldegheri L, Harries MH, Bioorganic and Medicinal Chemistry Letters . 2010,第23期

机译：N-取代的吡咯烷和四氢呋喃作为新型AMPAR正调节剂。
2. Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo(3,4-d)pyrimidines as novel mGluR4 positive allosteric modulators. [J] . Niswender CM, Lebois EP, Luo Q, Bioorganic and Medicinal Chemistry Letters . 2008,第20期

机译：代谢谷氨酸受体亚型4（MGLUR4）的正变形调节剂：第I部分。吡唑（3,4-D）嘧啶作为新型MGLUR4阳性变构调节剂的发现。
3. INTERMOLECULAR HYDROGEN BONDING BETWEEN N-SUBSTITUTED CAPROAMIDES AND TETRAHYDROFURAN [J] . B. Jovic, A. Nikolic, B. Hollo Журнал струκтурной химии . 2013,第2期

机译：N-取代的己酰胺与四氢呋喃之间的分子间氢键
4. Low-energy positron and electron scattering from tetrahydrofuran and 3- hydroxy-tetrahydrofuran [C] . J. P. Sullivan, L. Chiari, E. Anderson, ICPEAC . 2014

机译：来自四氢呋喃和3-羟基四氢呋喃的低能量正电子和电子散射
5. Powerful three-component/one-pot asymmetric protocol for synthesizing chiral tryptophan derivatives, and, An investigation into the decomposition of borane-tetrahydrofuran complex in tetrahydrofuran through accelerated thermal decomposition studies and stabilization by Lewis base [D] . Todd, Robert C. 2008

机译：强大的三组分/一锅不对称合成手性色氨酸衍生物的方法，以及通过加速热分解研究和路易斯碱稳定化研究四氢呋喃中硼烷-四氢呋喃配合物的分解
6. Synthesis of Chiral Tetrahydrofurans and Pyrrolidines by Visible‐Light‐Mediated Deoxygenation [O] . Daniel Rackl, Viktor Kais, Eugen Lutsker, -1

机译：可见光介导的脱氧合成手性四氢呋喃和吡咯烷
7. An easy access to two epimeric N-substituted (2S)-2-(2'-hydroxypropyl)pyrrolidines [O] . Maria Joselice e Silva, Louis Cottier, Rajendra M. Srivastava, 2005

机译：易于进入两个基础二取代（2S）-2-（2'-羟丙基）吡咯烷

N-substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators.

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