Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.

Young RJ; Alderton W; Angell AD; Beswick PJ; Brown D; Chambers CL; Crowe MC; Dawson J; Hamlett CC; Hodgson ST; Kleanthous S; Knowles RG; Russell LJ; Stocker R; Woolven JM

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.

【24h】

Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.

机译：杂环脂族羧am作为诱导型一氧化氮合酶的抑制剂; （2R）-2-吡咯烷羧am作为强效和选择性的血红素配位抑制剂的鉴定。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Heteroalicyclic carboxamidines were synthesised and evaluated as inhibitors of nitric oxide synthases. (2R)-2-Pyrrolidinecarboxamidine, in particular, was shown to be a highly potent in vitro (IC(50)=0.12 muM) and selective iNOS inhibitor (>100-fold vs both eNOS and nNOS), with probable binding to the key anchoring glutamate residue and co-ordination to the haem iron.

机译：合成杂环脂族car并评估其为一氧化氮合酶的抑制剂。特别是（2R）-2-吡咯烷甲box在体外具有很强的作用（IC（50）= 0.12μM）和选择性iNOS抑制剂（相对于eNOS和nNOS而言> 100倍），并且可能与关键锚固谷氨酸残基并与血红素铁配位。

著录项

来源
《Bioorganic and Medicinal Chemistry Letters》 |2011年第10期|共4页
作者
Young RJ; Alderton W; Angell AD; Beswick PJ; Brown D; Chambers CL; Crowe MC; Dawson J; Hamlett CC; Hodgson ST; Kleanthous S; Knowles RG; Russell LJ; Stocker R; Woolven JM;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor. [J] . Young RJ, Alderton W, Angell AD, Bioorganic and Medicinal Chemistry Letters . 2011,第10期

机译：杂环脂族羧am作为诱导型一氧化氮合酶的抑制剂; （2R）-2-吡咯烷羧am作为强效和选择性的血红素配位抑制剂的鉴定。
2. 3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: A potent and highly selective inducible nitric oxide synthase inhibitor. [J] . Tsymbalov S, Hagen TJ, Moore WM, Bioorganic and Medicinal Chemistry Letters . 2002,第22期

机译：3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine：一种有效且高度选择性的诱导型一氧化氮合酶抑制剂。
3. 3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: A potent and highly selective inducible nitric oxide synthase inhibitor. [J] . Tsymbalov S, Hagen TJ, Moore WM, Bioorganic and Medicinal Chemistry Letters . 2002,第22期

机译：3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine：一种有效且高度选择性的诱导型一氧化氮合酶抑制剂。
4. Pulmonary Arterial Pressure and Electrocardiograms in Broiler Chickens Infused Intravenously with L-NAME, an Inhibitor of Nitric Oxide Synthase, or Sodium Nitroprusside (SNP), a Nitric Oxide Donor [C] . Wei-Dong Sun, Xiao-Long Wang, Jin-Yong Wang, International Conference on Avian Nutritional and Metabolic Disorders; 20060414-17; Nanjing(CN) . 2006

机译：静脉输注一氧化氮合酶抑制剂L-NAME或一氧化氮供体硝普钠（SNP）的肉鸡的肺动脉压和心电图
5. Differences in the activation of endothelial and neuronal nitric oxide synthase by oxidized calmodulin, and multiphoton activation of a photo-sensitive nitric oxide synthase inhibitor. [D] . Montgomery, Heather Jane. 2004

机译：氧化钙调蛋白活化内皮和神经元一氧化氮合酶的差异，以及光敏一氧化氮合酶抑制剂的多光子活化。
6. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo [O] . Wendy K Alderton, Anthony D R Angell, Caroline Craig, 2005

机译：GW274150和GW273629是有效的高选择性诱导型一氧化氮合酶抑制剂
7. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo [O] . Alderton, Wendy K, Angell, Anthony D R, Craig, Caroline, 2005

机译：GW274150和GW273629是有效的高选择性诱导型一氧化氮合酶抑制剂
8. Immediate Force Loss after Eccentric Contractions is Increased with L-NAME Administration, a Nitric Oxide Synthase Inhibitor. [R] . Corona, B. T., Ingalls, C. P. 2013

机译：一次一氧化氮合成酶抑制剂L-NamE给药后，离心收缩后即刻的力量损失增加。

Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.

摘要

著录项

相似文献

相关主题

期刊订阅