Synthesis and application of an N-acylated l-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors.

Praneenararat T; Beary TM; Breitbach AS; Blackwell HE

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Synthesis and application of an N-acylated l-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors.

机译：N-酰化的L-高丝氨酸内酯衍生的亲和基质的合成和应用，用于分离群体感应信号受体。

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The design and synthesis of an agarose resin functionalized with a Gram-negative quorum sensing (QS) signaling molecule analogue is described. The modified resin was utilized in affinity pull-down assays to successfully isolate QscR, a LuxR-type QS receptor from Pseudomonas aeruginosa. This resin may facilitate the identification of novel QS signal receptors using affinity chromatography techniques.

机译：描述了用革兰氏阴性群体感应（QS）信号分子类似物功能化的琼脂糖树脂的设计和合成。改性树脂用于亲和力下拉分析中，成功地从铜绿假单胞菌中分离出QscR（一种LuxR型QS受体）。该树脂可以使用亲和色谱技术促进新型QS信号受体的鉴定。

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《Bioorganic and Medicinal Chemistry Letters》 |2011年第17期|共4页
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Praneenararat T; Beary TM; Breitbach AS; Blackwell HE;
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1. Synthesis and application of an N-acylated l-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors. [J] . Praneenararat T, Beary TM, Breitbach AS, Bioorganic and Medicinal Chemistry Letters . 2011,第17期

机译：N-酰化的L-高丝氨酸内酯衍生的亲和基质的合成和应用，用于分离群体感应信号受体。
2. Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxo-dodecanoyl)-L-homoserine lactone triggers mitochondrial dysfunction and apoptosis in neutrophils through calcium signaling [J] . Singh Pradeep Kumar, Yadav Vivek Kumar, Kalia Manmohit, Medical Microbiology and Immunology . 2019,第6期

机译：假单胞菌铜绿假单胞菌批量传感分子N-（3-氧代 - 十二烷酰）-L-甲晶内酯通过钙信号传导触发线性粒细胞功能障碍和中性粒细胞的凋亡
3. Structure-Function Analyses of the N-Butanoyl L-Homoserine Lactone Quorum-Sensing Signal Define Features Critical to Activity in RhIR [J] . Boursier Michelle E., Moore Joseph D., Heitman Katherine M., ACS Chemical Biology . 2018,第9期

机译：正丁烷酰L-HomoSerine内酯频率测定信号的结构 - 功能分析定义对rhir活动至关重要的特征
4. Isolation of Biofilm-Forming Bacteria from the Secondary Effluent of the Wastewater Treatment Plant and its Ability to Produce N-Acylhomoserine Lactone as Quorum Sensing Signal [C] . Eri Nasuno, Yuto Abe, Ken-ichi Iimura, International Conference on Advanced Materials, Mechanics and Structural Engineering . 2017

机译：从废水处理厂的二次流出物中分离生物膜形成细菌及其生产N-酰基骨内酯的能力作为判定信号
5. New avenues and applications for parallel library synthesis: I. Application of multicomponent reactions for the efficient synthesis of small molecule macroarrays. II. Characterization of non-native N-acylated L-homoserine lactones as bacterial biofilm inhibitors [D] . Lin, Qi 2007

机译：平行文库合成的新途径和应用：I.多组分反应在小分子大分子阵列有效合成中的应用。二。非天然N-酰化L-高丝氨酸内酯作为细菌生物膜抑制剂的表征
6. Synthesis and application of an N-acylated L-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors [O] . Thanit Praneenararat, Teresa M. J. Beary, Anthony S. Breitbach, -1

机译：N-酰化L-型甲酸酯内酯衍生化亲和力基质的合成与应用用于分离仲裁传感信号受体
7. Potent and Selective Synthetic Modulators of a Quorum Sensing Repressor in Pseudomonas aeruginosa Identified from Second-Generation Libraries of N-Acylated L-Homoserine Lactones [O] . Margrith E. Mattmann, Patrick M. Shipway, Nicole J. Heth, 2011

机译：铜绿假单胞菌的Quorum传感阻遏物的有效和选择性合成调节剂，其从N-酰化L-型甲状甲虫的第二代文库中鉴定
8. Octanoyl-Homoserine Lactone Is the Cognate Signal for Burkholderia mallei BmaR1-BmaI1 Quorum Sensing [R] . Duerkop, B. A. , Ulrich, R. L. , Greenberg, E. P. 2007

机译：Octanoyl-Homoserine Lactone是Burkholderia mallei BmaR1-BmaI1群体感应的同源信号

Synthesis and application of an N-acylated l-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors.

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