A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor.

Bach P; Bostrom J; Brickmann K; van Giezen JJ; Hovland R; Petersson AU; Ray A; Zetterberg F

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A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor.

机译：一系列新型的哌嗪基-吡啶尿素作为嘌呤能P2Y12受体的拮抗剂。

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A novel series of P2Y(12) antagonists for development of drugs within the antiplatelet area is presented. The synthesis of the piperazinyl-pyridine urea derivatives and their structure-activity relationships (SAR) are described. Several compounds showed P2Y(12) antagonistic activities in the sub-micromolar range.

机译：提出了一系列新的P2Y（12）拮抗剂，用于在抗血小板区域内开发药物。描述了哌嗪基-吡啶脲衍生物的合成及其结构-活性关系（SAR）。几种化合物在亚微摩尔范围内显示P2Y（12）拮抗活性。

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《Bioorganic and Medicinal Chemistry Letters》 |2011年第10期|共5页
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Bach P; Bostrom J; Brickmann K; van Giezen JJ; Hovland R; Petersson AU; Ray A; Zetterberg F;
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1. A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor. [J] . Bach P, Bostrom J, Brickmann K, Bioorganic and Medicinal Chemistry Letters . 2011,第10期

机译：一系列新型的哌嗪基-吡啶尿素作为嘌呤能P2Y12受体的拮抗剂。
2. Molecular modeling of purinergic receptor P2Y12 and interaction with its antagonists [J] . Zhan C, Yang J, Dong XC, Journal of molecular graphics & modelling . 2007,第1期

机译：嘌呤能受体P2Y12的分子模型及其与其拮抗剂的相互作用
3. Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor. [J] . Hoffmann K, Baqi Y, Morena MS The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2009,第2期

机译：新的，非常有效的非核苷酸拮抗剂与人血小板P2Y12受体Arg256的相互作用。
4. Design of a Series Variable Stiffness Joint Based on Antagonistic Principle [C] . Shipeng Cui, Yiwei Liu, Yongjun Sun, International conference on intelligent robotics and applications . 2017

机译：基于对抗原理的系列变刚度接头设计
5. Agonist and antagonist interactions with the nicotinic acetylcholine receptor. [D] . Hong, Filbert Hui-pek. 2004

机译：激动剂和拮抗剂与烟碱乙酰胆碱受体的相互作用。
6. Targetable purinergic receptors P2Y12 and A2b antagonistically regulate bladder function [O] . Yuan Hao, Lu Wang, Huan Chen, 2019

机译：靶向嘌呤能受体P2Y12和A2b拮抗膀胱功能
7. ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12 [O] . Loreen Kloss, Claudia Dollt, Kai Schledzewski, 2019

机译：通过染色黑色素瘤细胞分泌的ADP通过嘌呤能受体P2Y12介导培养的趋化性和趋化因子分泌巨噬细胞分泌

A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor.

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