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首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >GPCR structures in drug design, emerging opportunities with new structures
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GPCR structures in drug design, emerging opportunities with new structures

机译：药物设计中的GPCR结构，新结构带来的新机遇

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摘要

In recent years, GPCR targets from diverse regions of phylogenetic space have been determined. This effort has culminated this year in the determination of representatives of all major classes of GPCRs (A, B, C, and F). Although much of the now well established knowledge on GPCR structures has been known for some years, the new high-resolution structures allow structural insight into the causes of ligand efficacy, biased signaling, and allosteric modulation. In this digest the structural basis for GPCR signaling in the light of the new structures is reviewed and the use of the new non-class A GPCRs for drug design is discussed.
机译：近年来，已确定了来自系统发育空间各个区域的GPCR靶标。今年，这项工作最终决定了GPCR的所有主要类别（A，B，C和F）的代表。尽管已经有很多有关GPCR结构的知识，这些新的高分辨率结构使我们能够深入了解配体功效，偏向信号传导和变构调节的原因。在本摘要中，根据新结构回顾了GPCR信号转导的结构基础，并讨论了将新的非A类GPCR用于药物设计的情况。

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