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首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Development of potential selective and reversible pyrazoline based MAO-B inhibitors as MAO-B PET tracer precursors and reference substances for the early detection of Alzheimer's disease
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Development of potential selective and reversible pyrazoline based MAO-B inhibitors as MAO-B PET tracer precursors and reference substances for the early detection of Alzheimer's disease

机译：开发潜在的选择性和可逆吡唑啉基MAO-B抑制剂作为MAO-B PET示踪剂前体和参考物质，用于早期发现阿尔茨海默氏病

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Since high MAO-B levels are present in early stages of AD, the MAO-B system can be designated as an appropriate and prospective tracer target of molecular imaging biomarkers for the detection of early AD. According to the preceding investigations of Mishra et al. the aim of this work was the development of a compound library of selective and reversible MAO-B inhibitors by performing bioisosteric modifications of the core structure of 3-(anthracen-9-yl)-5-phenyl-4,5-dihydro-1H-pyrazoles. In conclusion, 13 new pyrazoline based derivatives have been prepared, which will serve as precursor substances for future radiolabeling as well as reference compounds for the investigation of increased MAO-B levels in AD. (C) 2014 Elsevier Ltd. All rights reserved.
机译：由于AD的早期阶段存在较高的MAO-B水平，因此可以将MAO-B系统指定为检测早期AD的分子成像生物标记物的合适且预期的示踪剂目标。根据Mishra等人的先前调查。这项工作的目的是通过对3-（蒽-9-基）-5-苯基-4,5-二氢-1H的核心结构进行生物立体修饰来开发选择性和可逆MAO-B抑制剂化合物库-吡唑类。总之，已经制备了13种新的基于吡唑啉的衍生物，这些衍生物将用作未来放射性标记的前体物质以及研究AD中MAO-B水平升高的参考化合物。 （C）2014 Elsevier Ltd.保留所有权利。

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