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首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Polybrominated diphenyl ethers with potent and broad spectrum antimicrobial activity from the marine sponge Dysidea
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Polybrominated diphenyl ethers with potent and broad spectrum antimicrobial activity from the marine sponge Dysidea

机译：海洋海绵Dysidea具有强效和广谱抗菌活性的多溴二苯醚

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摘要

Three polybrominated diphenyl ethers,2-(2',4'-dibromophenoxy)-3,5-dibromophenol (1) and 2-(2',4'-dibromophenoxy)- 3,4,5-tribromophenol (2) were isolated from the marine sponge Dysidea granulosa; and 2-(2',4'-dibromophenoxy)-4,6-dibromophenol (3) from Dysidea spp. They exhibited potent and broad spectrum in vitro antibacterial activity, especially against methicillin resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), Escherichia coli O157:H7, and Salmonella. Minimal inhibitory concentration (MIC) was evaluated against 12 clinical and standard strains of Gram positive and negative bacteria. The observed MIC range was 0.1-4.0 mg/L against all the Gram positive bacteria and 0.1-16.0 mg/L against Gram negative bacteria. 2-(2',4 ''-Dibromophenoxy)-3,5-dibromophenol showed stronger broad spectrum antibacterial activity than other two compounds. 2-(2',4 ''-Dibromophenoxy)-3,5-dibromophenol and 2-(2',4'-dibromophenoxy)-4,6-dibromophenol are thermo-stable. The results suggest that 2-(2',4'-dibromophenoxy)-3,5-dibromophenol could be used as a potential lead molecule for anti-MRSA, anti-Escherichia coli O157:H7, and anti-Salmonella for drug development. (C) 2015 Elsevier Ltd. All rights reserved.
机译：分离了三种多溴二苯醚，2-（2'，4'-二溴苯氧基）-3,5-二溴苯酚（1）和2-（2'，4'-二溴苯氧基）-3,4,5-三溴苯酚（2）来自海洋海绵Dysidea granulosa;和来自Dysidea spp的2-（2'，4'-dibromophenoxy）-4,6-dibromophenol（3）。它们在体外表现出有效和广谱的抗菌活性，特别是对耐甲氧西林的金黄色葡萄球菌（MRSA），耐甲氧西林的金黄色葡萄球菌（MSSA），大肠杆菌O157：H7和沙门氏菌。针对12株革兰氏阳性和阴性细菌的临床和标准菌株评估了最低抑菌浓度（MIC）。对所有革兰氏阳性细菌观察到的MIC范围为0.1-4.0 mg / L，对革兰氏阴性细菌观察到的MIC范围为0.1-16.0 mg / L。 2-（2'，4''-二溴苯氧基）-3,5-二溴苯酚显示出比其他两种化合物更强的广谱抗菌活性。 2-（2′，4′-二溴苯氧基）-3，5-二溴苯酚和2-（2′，4′-二溴苯氧基）-4，6-二溴苯酚是热稳定的。结果表明，2-（2'，4'-dibromophenoxy）-3,5-dibromophenol可用作抗MRSA，抗大肠杆菌O157：H7和抗沙门氏菌的潜在先导分子，用于药物开发。 （C）2015 Elsevier Ltd.保留所有权利。

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