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首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity
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Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity

机译：越橘越橘中的倍他隆醇皂苷及其抗炎活性

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摘要

Using various chromatographic methods, five new steroidal saponins named taccavietnamosides A-E (1-5) and three known, (24S,25R)-spirost-5-en-3 beta,24-diol 3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-[alpha-L-rhamnopyranosyl-(1 -> 3)]-beta-D-glucopyranoside (6), (24S, 25R)-spirost-5-en-3b, 24-diol 3-O-alpha-Lrhamnopyranosyl-(1 -> 2)-[beta-D-glucopyranosyl-(1 -> 4)-alpha-L-rhamnopyranosyl-(1 -> 3)]-beta-D-glucopyranoside (7), and chantrieroside A(8) were isolated from the rhizomes of Tacca vietnamensis Thin et Hoat. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated RAW 264.7 macrophages and BV2 cells. As the results, compounds 3-5 showed moderate inhibition on NO production in LPS-stimulated BV2 cells and RAW 264.7 macrophages with the IC50 values ranging from 37.0 to 60.7 mu M. (C) 2016 Elsevier Ltd. All rights reserved.
机译：使用各种色谱方法，命名为taccavietnamosides AE（1-5）的五种新的甾体皂苷和（24S，25R）-spirost-5-en-3 beta，24-二醇3-O-alpha-L-鼠李糖基-（ 1-> 2）-[α-L-鼠李吡喃糖基-（1-> 3）]-β-D-吡喃葡萄糖苷（6），（24S，25R）-spirost-5-en-3b，24-diol 3-O -α-鼠李吡喃糖基-（1-> 2）-[β-D-吡喃吡喃糖基-（1-> 4）-α-L-鼠李糖吡喃糖基-（1-> 3）]-β-D-吡喃葡糖苷（7），和黄side苷A（8）是从越橘越橘的根茎中分离得到的。通过物理和化学方法阐明了它们的化学结构。评价所有化合物对LPS刺激的RAW 264.7巨噬细胞和BV2细胞中一氧化氮生成的抑制活性。结果，化合物3-5在LPS刺激的BV2细胞和RAW 264.7巨噬细胞中显示出对NO产生的中度抑制，IC50值为37.0至60.7μM。（C）2016 Elsevier Ltd.保留所有权利。

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