Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors

Dwyer Michael P.; Keertikar Kerry M.; Chen Lei; Tong Ling; Selyutin Oleg; Nair Anilkumar G.; Yu Wensheng; Zhou Guowei; Lavey Brian J.; Yang De-Yi; Wong Michael; Kim Seong Heon; Coburn Craig A.; Rosenblum Stuart B.; Zeng Qingbei; Jiang Yueheng; Shankar Bandarpalle B.; Rizvi Razia; Nomeir Amin A.; Liu Rong; Agrawal Sony; Xia Ellen; Kong Rong; Zhai Ying; Ingravallo Paul; Asante-Appiah Ernest; Kozlowski Joseph A.

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Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors

机译：HCV NS5A抑制剂四环吲哚类的匹配和混合帽衍生物

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A matched and mixed capping SAR study was conducted on the tetracyclic indole class of HCV NS5A inhibitors to examine the influence of modifications of this region on the overall HCV virologic resistance profiles. (C) 2016 The Authors. Published by Elsevier Ltd. All rights reserved.

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《Bioorganic and Medicinal Chemistry Letters》 |2016年第16期|共6页
作者
Dwyer Michael P.; Keertikar Kerry M.; Chen Lei; Tong Ling; Selyutin Oleg; Nair Anilkumar G.; Yu Wensheng; Zhou Guowei; Lavey Brian J.; Yang De-Yi; Wong Michael; Kim Seong Heon; Coburn Craig A.; Rosenblum Stuart B.; Zeng Qingbei; Jiang Yueheng; Shankar Bandarpalle B.; Rizvi Razia; Nomeir Amin A.; Liu Rong; Agrawal Sony; Xia Ellen; Kong Rong; Zhai Ying; Ingravallo Paul; Asante-Appiah Ernest; Kozlowski Joseph A.;
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正文语种 eng
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关键词
Hepatitis C; NS5A; Infectious diseases; Indole; Capping;

机译：丙型肝炎;NS5A;传染病;吲哚;封端;

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专利

1. Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors [J] . Dwyer Michael P., Keertikar Kerry M., Chen Lei, Bioorganic and Medicinal Chemistry Letters . 2016,第16期

机译：HCV NS5A抑制剂四环吲哚类的匹配和混合帽衍生物
2. Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors [J] . Tong Ling, Yu Wensheng, Coburn Craig A., Bioorganic and Medicinal Chemistry Letters . 2016,第20期

机译：围绕四环吲哚类HCV NS5A抑制剂的替代性核心开发
3. Structure-activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors [J] . Tong Ling, Yu Wensheng, Coburn Craig A., Bioorganic and Medicinal Chemistry Letters . 2016,第21期

机译：四环吲哚类NS5A抑制剂周围脯氨酸修饰的构效关系
4. Diarylaniline Derivatives as a Distinct Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors [C] . Bingjie Qin, Shibo Jiang, Kuo-Hsiung Lee, ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

机译：二芳基苯胺衍生物作为HIV-1非核苷逆转录酶抑制剂的一类。
5. Part I - Synthesis of the tetracyclic skeleton of the Lycopodium alkaloid lycopladine H Part II - Synthesis of the tetracyclic core of the apparicine class of indole alkaloids via a key intermolecular nitrosoalkene conjugate addition. [D] . Chauhan, Pradeep S. 2015

机译：第一部分-通过关键的分子间亚硝基链烯共轭物的添加，合成淫羊Ly生物碱番茄红素H的四环骨架。第二部分-合成吲哚生物碱类装置的四环核。
6. A Novel Simple Assay System to Quantify the Percent HCV-RNA Levels of NS5A Y93H Mutant Strains and Y93 Wild-Type Strains Relative to the Total HCV-RNA Levels to Determine the Indication for Antiviral Therapy with NS5A Inhibitors [O] . Yoshihito Uchida, Jun-ichi Kouyama, Kayoko Naiki, -1

机译：一种新颖的简单测定系统可量化NS5A Y93H突变株和Y93野生型菌株相对于总HCV-RNA水平的HCV-RNA百分比以确定使用NS5A抑制剂进行抗病毒治疗的适应症
7. Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors [O] . Tong Ling, Yu Wensheng, Coburn Craig A., 2016

机译：围绕四环吲哚类HCV NS5A抑制剂的替代性核心开发
8. Chemotherapeutic Potential of G1 Cell Cycle Inhibitor Indole-3-Carbinol and Its More Potent N-Alkoxy Derivatives in Human Breast Cancer Xenografts in Mice [R] . Kerekatte, V. S. , Firestone, G. 2004

机译：G1细胞周期抑制剂吲哚-3-甲醇及其更有效的N-烷氧基衍生物在小鼠人乳腺癌异种移植物中的化疗潜力

Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors

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