DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity

Vodnala Sumathi; Bhavani A. K. D.; Kamutam Ramakrishna; Naidu V. G. M.; Promila; Prabhakar Ch.

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DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity

机译：DABCO催化二氢吡喃并[3,2-c]色烯取代的喹唑啉的一锅三组分合成及其对抗癌活性的评价

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A facile DABCO promoted one-pot three component synthesis of a new series of C-C linked bis-hetero-cycle containing dihydropyrano[c]chromene as highly fused oxa-heteryl group at C-2 position of quinazoline was developed. Quinazoline-2-carbaldehyde, substituted 4-hydroxycoumarin and ethyl cyanoacetate were used as key components in the Knoevenagel-Michael addition reaction to get the titled compounds. These compounds were screened for anti-cancer activity against the breast cancer cell lines of MDA-MB 231, and MDA-MB 453. (C) 2016 Elsevier Ltd. All rights reserved.

机译：开发了一种简便的DABCO促进了一系列新的一系列C-C连接的双杂环的单组分三组分合成，该双杂环包含二氢吡喃并[c]苯甲基作为喹唑啉C-2位的高度稠合的氧杂杂基。喹唑啉-2-甲醛，取代的4-羟基香豆素和氰基乙酸乙酯用作Knoevenagel-Michael加成反应的关键组分，得到标题化合物。筛选了这些化合物对MDA-MB 231和MDA-MB 453乳腺癌细胞系的抗癌活性。（C）2016 Elsevier Ltd.保留所有权利。

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《Bioorganic and Medicinal Chemistry Letters》 |2016年第16期|共5页
作者
Vodnala Sumathi; Bhavani A. K. D.; Kamutam Ramakrishna; Naidu V. G. M.; Promila; Prabhakar Ch.;
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Multicomponent reaction; Knoevenagel-Michael reaction; Quinazoline; 4-Hydroxycoumarin; DABCO; Anti-cancer;

机译：多组分反应;Knoevenagel-Michael反应;喹唑啉;4-羟基香豆素;DABCO;抗癌;

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1. DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity [J] . Vodnala Sumathi, Bhavani A. K. D., Kamutam Ramakrishna, Bioorganic and Medicinal Chemistry Letters . 2016,第16期

机译：DABCO催化二氢吡喃并[3,2-c]色烯取代的喹唑啉的一锅三组分合成及其对抗癌活性的评价
2. Synthesis of a novel piperidine-functionalized poly(ethylene glycol) bridged dicationic ionic liquid and its application in one-pot synthesis of substituted 2-amino-2-chromenes and 3,4-dihydropyrano[3,2-c]chromenes in aqueous media [J] . Yinglei Wang, Jun Luo, Tantan Xing Monatshefte fur Chemie . 2013,第12期

机译：新型哌啶官能化的聚乙二醇桥接的双键离子液体的合成及其在水介质中一锅法合成取代的2-氨基-2-色烯和3,4-二氢吡喃[3,2-c]色烯的应用
3. Saccharose as a new, natural, and highly efficient catalyst for the one-pot synthesis of 4,5-dihydropyrano[3,2-c]chromenes, 2-amino-3-cyano-4H-chromenes, 1,8-dioxodecahydroacridine, and 2-substituted benzimidazole derivatives [J] . Maghsoodlou Malek Taher, Hazeri Nourallah, Lashkari Mojtaba, Research on Chemical Intermediates . 2015,第10期

机译：蔗糖是一种新型，天然且高效的催化剂，可用于一锅合成4,5-二氢吡喃并[3,2-c]色烯，2-氨基-3-氰基-4H-色烯，1,8-二氧代十二氢化hydro啶，和2-取代的苯并咪唑衍生物
4. Efficient Synthesis and Herbicidal Activity Of Benzofuranyl and Chromene Substituted Pyrazoles(Abstracts) [C] . Jurgen Schaetzer, Kurt Nebel European Symposium on Organic Chemistry . 2007

机译：苯并呋喃基和染色体取代吡唑（摘要）的高效合成和除草活性
5. Design, synthesis and evaluation of some novel substituted quinazolines as antihypertensive and antihistaminic agents. [D] . Alagarsamy, V. 2015

机译：设计，合成和评估一些新型的取代喹唑啉类抗高血压药和抗组胺药。
6. Ultrasound Mediated One-Pot Three Component Synthesis Docking and ADME Prediction of Novel 5-Amino-2-(4-chlorophenyl)-7-Substituted Phenyl-88a-dihydro-7H-(134)thiadiazolo(32-α)pyrimidine-6-carbonitrile Derivatives as Anticancer Agents [O] . Shailee V. Tiwari, Julio A. Seijas, M. Pilar Vazquez-Tato, 2016

机译：超声介导的新型5-氨基-2-（4-氯苯基）-7取代苯基-88a-二氢-7H-（134）噻二唑的一锅三组分合成对接和ADME预测32-α）嘧啶-6-腈衍生物作为抗癌药
7. Three-Component Synthesis of Mono and Bis 4,5-Dihydropyrano[3,2-C]Chromenes and 4,5- Dihydropyran[4,3-B]Pyrans Catalyzed by Sodium Benzenesulfinates as a Green Organocatalyst [O] . Abaszadeh Mehdi, Seifi Mohammad 2017

机译：由苯亚磺酸钠作为绿色有机催化剂催化的单组分合成单和双4,5-二氢吡喃并[3,2-C]铬和4,5-二氢吡喃[4,3-B]吡喃

DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity

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