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首页> 外文期刊>Brain research >Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampus.
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Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampus.

机译：非人类灵长类海马体中GABA（A）受体亚基的年龄相关变化。

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摘要

Pharmacological studies have documented that altered drug responses, particularly to benzodiazepines, are common in elderly populations. While numerous factors may contribute to changes in drug response, age-related alterations in the molecular composition of GABA(A) receptors may be a key factor in regulating these responses. We employed quantitative densitometry to examine the cytological features and density of highly prevalent hippocampal GABA(A) receptor subunits (alpha1 and beta2/3) in young and aged rhesus monkeys. alpha1 and beta2/3 subunit immunostaining was differentially distributed throughout the hippocampus. In addition, beta2/3 immunolabeling in aged monkeys was characterized by marked intersubject variability in labeling intensity, with dramatic reductions present in 3 of 5 samples. alpha1 immunolabeling in aged monkeys was significantly reduced in the CA2 and CA3 subregions, and in hilus/polymorphic layer of the dentate gyrus. Collectively, our findings demonstrate that not only are GABA(A) receptor subunits differentially distributed throughout the hippocampus, but they are also differentially altered with increased age--changes that may have an important impact on the binding properties of GABA(A) receptor pharmacological agents.
机译：药理学研究表明，改变药物反应，特别是对苯二氮卓类药物的反应在老年人群中很常见。尽管许多因素可能会导致药物反应的变化，但与年龄相关的GABA（A）受体分子组成的变化可能是调节这些反应的关键因素。我们采用定量光密度法来检查幼年和成年恒河猴中高度流行的海马GABA（A）受体亚基（alpha1和beta2 / 3）的细胞学特征和密度。 alpha1和beta2 / 3亚基免疫染色分布在整个海马区。此外，在衰老的猴子中，β2/ 3免疫标记的特征在于标记强度显着的个体间差异，在5个样本中的3个中显着降低。在CA2和CA3子区域以及齿状回的hilus /多态层中，成年猴子的alpha1免疫标记显着减少。总的来说，我们的研究结果表明，不仅GABA（A）受体亚基在整个海马体中分布不同，而且随着年龄的增长，它们也有差异性的变化-这种变化可能对GABA（A）受体的药理学性质产生重要影响代理商。

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