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首页> 外文期刊>Brain research >GABAergic neurons in the ventrolateral subnucleus of the nucleus tractus solitarius are in contact with Kolliker-Fuse nucleus neurons projecting to the rostral ventral respiratory group and phrenic nucleus in the rat.
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GABAergic neurons in the ventrolateral subnucleus of the nucleus tractus solitarius are in contact with Kolliker-Fuse nucleus neurons projecting to the rostral ventral respiratory group and phrenic nucleus in the rat.

机译：孤束核腹外侧亚核中的GABA能神经元与投射到大鼠腹侧腹呼吸组和核的Kolliker-Fuse核神经元接触。

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摘要

After ipsilateral injections of biotinylated dextran amine (BDA) into the ventrolateral subnucleus of the nucleus tractus solitarius (vlNTS) and Fluoro-gold (FG) into the rostral ventral respiratory group (rVRG) region or into the phrenic nucleus (PhN) region in the rat, an overlapping distribution of BDA-labeled axon terminals and FG-labeled neurons was found in the Kolliker-Fuse (KF) nucleus ipsilateral to the injection sites. Using retrograde tracing combined with immunohistochemistry for glutamic acid decarboxylase isoform 67 (GAD67), we indicated that as many as 40% of the vlNTS neurons projecting to the KF were immunoreactive for GAD67. Using a combination of anterograde and retrograde tracing techniques, and immunohistochemistry for GAD67, we further demonstrated that the vlNTS axon terminals with GAD67 immunoreactivity established close contact to the rVRG- or PhN-projecting KF neurons. The present results suggest that GABAergic vlNTS fibers may exert inhibitory influences on the rVRG- as well as PhN-projecting KF neurons and these circuits may be involved in the respiratory reflexes such as the Hering-Breuer reflex.
机译：将同种生物素化的右旋糖酐胺（BDA）同侧注射到孤束核（vlNTS）和氟金（FG）的腹侧亚核中后，进入鼻端腹侧呼吸组（rVRG）区域或the核（PhN）区域在大鼠中，在注射部位同侧的Kolliker-Fuse（KF）核中发现了BDA标记的轴突末端和FG标记的神经元的重叠分布。使用逆向示踪结合免疫组化的谷氨酸脱羧酶同工型67（GAD67），我们表明多达40％的投射到KF的vlNTS神经元对GAD67具有免疫反应性。结合顺行和逆行追踪技术以及GAD67的免疫组织化学，我们进一步证明具有GAD67免疫反应性的vlNTS轴突末端建立了与rVRG或PhN投射KF神经元的紧密接触。目前的结果表明，GABA能vlNTS纤维可能对rVRG以及PhN投射KF神经元产生抑制作用，并且这些回路可能参与呼吸反射，例如Hering-Breuer反射。

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