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首页> 外文期刊>Brain research >Dendritic spine density of posterodorsal medial amygdala neurons can be affected by gonadectomy and sex steroid manipulations in adult rats: a Golgi study.
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Dendritic spine density of posterodorsal medial amygdala neurons can be affected by gonadectomy and sex steroid manipulations in adult rats: a Golgi study.

机译：高尔基体研究显示，成年大鼠的性腺切除术和性激素治疗可影响后内侧内侧杏仁核神经元的树突棘密度。

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The posterodorsal medial amygdala (MePD) is a sex steroid-responsive area in the rat brain. The dendritic spine density of Golgi-impregnated MePD neurons were studied in: (1) adult gonadectomized (GDX) males after a short or a longer postcastration period (8 and 90 days, respectively), compared to age-matched sham operated and to intact controls; (2) adult GDX females, which received oil, estradiol benzoate (EB) alone or EB and progesterone as substitutive therapy; and, (3) EB-treated GDX females that concomitantly received saline or LY235959, a competitive antagonist of NMDA receptors, to test a possible glutamatergic mediation on the estrogen-mediated increase in spine density in this brain area. Intact males showed a higher spine density than males studied 8 days after sham operation or those in both short- and long-term GDX groups (p<0.02), but not when compared to males at 90 days after sham operation (p=0.12). In females, dendritic spine density increased following EB injections when compared to the oil group (p=0.05), with an effect that was potentiated by progesterone (p<0.01). LY235959 was not able to block the stimulating effect of EB on dendritic spines of GDX females (p>0.2). These data provide novel evidence that MePD dendritic spines are affected by sex steroid manipulations in adult rats, GDX males had a specific spine density decrease after a long postcastration period, and estrogen (apparently independently of a NMDA receptor interaction) and progesterone have stimulatory effects on the number of dendritic spines in GDX females.
机译：后内侧内侧杏仁核（MePD）是大鼠大脑中的性类固醇反应性区域。在以下情况下研究了高尔基浸渍的MePD神经元的树突棘密度：（1）与经过年龄匹配的假手术和完整假体相比，短或更长的后cast期（分别为8天和90天）后的成年性腺切除（GDX）男性。控制; （2）GDX成年雌性，仅接受油，苯甲酸雌二醇（EB）或EB和孕酮替代治疗; （3）同时接受生理盐水或NMDA竞争性拮抗剂LY235959的EB治疗的GDX雌性，以测试在该脑区域中雌激素介导的脊柱密度增加的可能谷氨酸能介导。完整的男性显示出比假手术后第8天或短期和长期GDX组研究的男性更高的脊柱密度（p <0.02），但与假手术后第90天的男性相比却没有（p = 0.12） 。在女性中，与油组相比，EB注射后树突棘密度增加（p = 0.05），黄体酮增强了这种作用（p <0.01）。 LY235959不能阻止EB对GDX雌性树突棘的刺激作用（p> 0.2）。这些数据提供了新的证据，表明成年大鼠中MePD树突棘受到性类固醇操纵的影响，经过长时间的cast割期后，GDX雄性大鼠的脊柱密度降低，雌激素（显然独立于NMDA受体相互作用）和孕酮对雌性激素有刺激作用。 GDX雌性中树突棘的数量。

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