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首页> 外文期刊>Brain research >Topography in the projections of lateral posterior thalamus with cingulate and medial agranular cortex in relation to circuitry for directed attention and neglect.
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Topography in the projections of lateral posterior thalamus with cingulate and medial agranular cortex in relation to circuitry for directed attention and neglect.

机译：与有扣带回和内侧的无皮质皮质相关的外侧丘脑后部投影中的地形，与定向注意和忽视的电路有关。

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In the rat, the lateral posterior thalamic nucleus (LP) has reciprocal connections with areas of the cortex and the striatum involved in directed attention and its dysfunctional counterpart, contralateral neglect. It has also been shown that the medial portion of the mediorostral part of LP (mLPMR) is of special interest because it has connections with the dorsocentral striatum, a key node in this circuitry. In the present study we used neuroanatomical tracers to map the specific connections and topography of LP with the anterior cingulate cortex (ACC) and medial agranular cortex (AGm). We primarily used Alexa Fluor conjugates of the retrograde tracer cholera toxin subunit B, and injected two different colored conjugates into ACC and AGm in the same animal in order to directly compare the differential topography of the thalamocortical connections of mLPMR. The bidirectional tracer, dextran amine, was also used to examine anterograde corticothalamic projections of AGm and ACC. We found that mLPMR consists of two distinct groups of neurons, with the more dorsal group projecting to ACC and the more ventral group projecting to AGm. This is mirrored by a similar corticothalamic topography. These findings suggest that the ventral mLPMR is specifically associated with AGm and dorsocentral striatum, while dorsal mLPMR is associated with ACC. They also suggest that ACC may play a role in the circuitry for directed attention and contralateral neglect, as it is known to do in humans.
机译：在大鼠中，外侧丘脑后核（LP）与参与定向注意的皮质和纹状体区域及其功能障碍的对侧疏忽对等连接。还已经表明，LP（mLPMR）的中腹部分的内侧部分特别令人关注，因为它与背中央纹状体（该电路中的关键节点）相连。在本研究中，我们使用神经解剖示踪剂来绘制LP与前扣带回皮层（ACC）和内侧无颗粒皮层（AGm）的特定连接和地形。我们主要使用逆行示踪霍乱毒素亚基B的Alexa Fluor偶联物，并在同一只动物的ACC和AGm中注射两种不同的有色偶联物，以便直接比较mLPMR的丘脑皮层连接的差异形貌。双向示踪剂右旋糖酐胺也用于检查AGm和ACC的顺行性皮层丘脑投射。我们发现，mLPMR由两个不同的神经元组组成，背侧组投射到ACC，腹侧组投射到AGm。相似的皮质丘陵地势反映了这一点。这些发现表明，腹侧mLPMR与AGm和背中央纹状体特别相关，而背侧mLPMR与ACC相关。他们还建议，ACC可能在定向注意和对侧忽视的电路中发挥作用，这在人类中是众所周知的。

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