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首页> 外文期刊>Brain research >Activation of ERK in the locus coeruleus following acute noxious stimulation.
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Activation of ERK in the locus coeruleus following acute noxious stimulation.

机译：急性有害刺激后蓝斑中ERK的激活。

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摘要

In the present study, the activation of extracellular signal-regulated kinase (ERK) in the locus coeruleus (LC) following injection of formalin or complete Freund's adjuvant (CFA) into the rat hindpaw was examined in order to clarify the mechanisms underlying the dynamic changes in the descending pain modulatory system after acute noxious stimulation or chronic inflammation. In naive rats there were few phospho-extracellular signal-regulated kinase-immunoreactive (p-ERK-IR) neurons in the LC. Formalin-, CFA- and saline-injections induced an increase in p-ERK-IR in the LC. The number of p-ERK-IR neurons in the LC in the formalin group was significantly higher than those in all other groups from 5 min to 1 h after the injection (p<0.05). CFA injection induced only a transient significant increase in the number of p-ERK-IR neurons and there was no significant difference in the number of p-ERK-IR neurons between the CFA and saline groups. At 5 min after formalin injection, almost all p-ERK-IR neurons in the LC were tyrosine hydroxylase (TH) -positive. These findings suggest that activation of ERK in the LC is induced by acute noxious stimulation, such as formalin injection, but not by CFA-induced chronic inflammation. The activation of ERK in the LC may be involved in the plasticity of the descending pain modulatory systems following acute noxious stimulation.
机译：在本研究中，研究了将福尔马林或完全弗氏佐剂（CFA）注入大鼠后爪后蓝斑（LC）中细胞外信号调节激酶（ERK）的活化，以阐明动态变化的机制急性有害刺激或慢性炎症后，在疼痛调节系统中下降。在幼稚大鼠中，LC中很少有磷酸化细胞外信号调节激酶免疫反应性（p-ERK-IR）神经元。注射福尔马林，CFA和盐水导致LC中p-ERK-IR升高。注射后5分钟至1小时，福尔马林组LC中p-ERK-IR神经元的数量显着高于所有其他组（p <0.05）。 CFA注射仅引起p-ERK-IR神经元数量的短暂显着增加，而CFA和盐水组之间的p-ERK-IR神经元数量没有显着差异。注射福尔马林后5分钟，LC中几乎所有p-ERK-IR神经元均为酪氨酸羟化酶（TH）阳性。这些发现表明，急性毒性刺激（例如福尔马林注射液）可诱导LC中ERK的活化，但CFA诱导的慢性炎症则不会。急性有害刺激后，LC中ERK的激活可能与下行疼痛调节系统的可塑性有关。

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