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首页> 外文期刊>Brain research >Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder: a functional magnetic resonance imaging study.
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Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder: a functional magnetic resonance imaging study.

机译：在地震引起的创伤后应激障碍中丘脑的静止状态功能连通性改变：功能磁共振成像研究。

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BACKGROUND: Thalamic dysfunction has been found in patients with posttraumatic stress disorder (PTSD), suggesting that the thalamus may be implicated in the etiology of PTSD. However, no studies have explored the functional connectivity between the thalamus and other brain regions during resting-state. The objective of the present study was to investigate the resting-state functional connectivity of the thalamus in recent onset medication-naive PTSD sufferers who went through an earthquake in the Sichuan province of China. METHODS: Fifty-four participants with PTSD and seventy-two age and gender matched traumatized controls without PTSD recruited from the 2008 Sichuan earthquake were scanned by 3T functional magnetic resonance imaging (fMRI) in resting state. Region of interest (ROI)-based functional connectivity analysis was employed to identify the potential differences in the functional connectivity of the thalamus between the two groups. RESULTS: In the PTSD group, the thalamus-ROIs showed decreased positive functional connectivity to particular brain regions including right medial frontal gyrus and left anterior cingulate cortex. Importantly, we also found increased positive functional connectivity of thalamus-ROIs with bilateral inferior frontal and left middle frontal gyri, left inferior parietal lobule as well as right precuneus in the PTSD participants when compared to traumatized controls without PTSD. CONCLUSION: The results provide evidence that abnormal resting state functional connections linking the thalamus to cortical regions may be involved in the underlying pathology in PTSD.
机译：背景：在创伤后应激障碍（PTSD）患者中发现丘脑功能障碍，提示丘脑可能与PTSD的病因有关。然而，尚无研究探讨丘脑和其他大脑区域在静止状态之间的功能连接性。本研究的目的是调查在中国四川省发生地震的最近未接受过药物治疗的PTSD患者的丘脑的静息状态功能连接。方法：在静息状态下，通过3T功能磁共振成像（fMRI）对54名PTSD参与者以及来自2008年四川地震的PTSD的72名年龄和性别匹配的受创伤对照进行了扫描。基于兴趣区域（ROI）的功能连接分析被用来识别两组之间丘脑功能连接的潜在差异。结果：在PTSD组中，丘脑-ROIs显示出与特定大脑区域（包括右内侧额回和左前扣带回皮质）的正向功能连通性降低。重要的是，与没有PTSD的受创伤对照相比，我们还发现PTSD参与者的丘脑-ROI与双侧下额叶和左中额回，左顶下小叶以及右前突的阳性功能连通性增加。结论：结果提供了证据，将丘脑与皮质区域连接的异常静止状态功能连接可能与PTSD的基础病理有关。

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