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Microglia function during brain development: New insights from animal models

机译:小胶质细胞在大脑发育过程中的功能:来自动物模型的新见解

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The role of microglia in healthy brains is just beginning to receive notice. Recent studies have revealed that these phagocytic cells control the patterning and wiring of the developing central nervous system (CNS) by regulating, amongst many other processes, programmed cell death, activity-dependent synaptic pruning and synapse maturation. Microglia also play important roles in the mature brain and have demonstrated effects on behavior. Converging evidence from human and mouse studies together raise questions as to the role of microglia in disorders of brain development such as autism and, schizophrenia. In this review, we summarize a number of major findings regarding the role of microglia in brain development and highlight some key questions and avenues for future study. This article is part of a Special Issue entitled SI: Neuroimmunology in Health And Disease. (C) 2015 Elsevier B.V. All rights reserved.
机译:小胶质细胞在健康大脑中的作用才刚刚开始受到关注。最近的研究表明,这些吞噬细胞可通过调节程序性细胞死亡,活性依赖性突触修剪和突触成熟等方法来控制发育中的中枢神经系统(CNS)的模式和布线。小胶质细胞在成熟的大脑中也起着重要作用,并已证明对行为有影响。来自人类和小鼠研究的越来越多的证据一起提出了关于小胶质细胞在诸如孤独症和精神分裂症之类的大脑发育障碍中的作用的疑问。在这篇综述中,我们总结了关于小胶质细胞在大脑发育中的作用的许多主要发现,并重点介绍了一些关键问题和未来研究的途径。本文是名为“ SI:健康与疾病中的神经免疫学”的特刊的一部分。 (C)2015 Elsevier B.V.保留所有权利。

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