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首页> 外文期刊>Brain research >Treadmill running restores MDMA-mediated hyperthermia prevented by inhibition of the dorsomedial hypothalamus
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Treadmill running restores MDMA-mediated hyperthermia prevented by inhibition of the dorsomedial hypothalamus

机译：跑步机运行可恢复MDMA介导的体温过高，可通过抑制背部丘脑下丘脑来预防

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摘要

The contribution of exercise to hyperthermia mediated by MDMA is not known. We recently showed that inhibiting the dorsomedial hypothalamus (DMH) attenuated spontaneous locomotion and hyperthermia and prevented deaths in rats given MDMA in a warm environment. The goal of this study was to confirm that restoring locomotion through a treadmill would reverse these effects thereby confirming that locomotion mediated by the DMH contributes to MDMA-mediated hyperthermia. Rats were randomized to receive bilateral microinjections, into the region of the DMH, of muscimol (80 pmoL/100 nl) or artificial CSF followed by a systemic dose of either MDMA (7.5 mg/kg, i.v.) or saline. Immediately after the systemic injection, rats were placed on a motorized treadmill maintained at 32 degrees C. Rats were exercised at a fixed speed (10 m/min) until their core temperature reached 41 degrees C. Our results showed that a fixed exercise load abolished the decreases in temperature and mortality, seen previously with inhibition of the DMH in freely moving rats. Therefore, locomotion mediated by neurons in the DMH is critical to the development of hyperthermia from MDMA. (C) 2015 Elsevier B.V. All rights reserved.
机译：运动对由MDMA介导的热疗的贡献尚不清楚。我们最近发现，抑制背部丘脑下丘脑（DMH）可以减弱自发运动和体温过高，并可以防止在温暖的环境中给予MDMA的大鼠死亡。这项研究的目的是确认通过跑步机恢复运动会逆转这些影响，从而确认DMH介导的运动有助于MDMA介导的体温过高。将大鼠随机分为两组，分别接受双分子微量注射麝香酚（80 pmoL / 100 nl）或人工CSF注射到DMH区域，然后全身注射MDMA（7.5 mg / kg，静脉内）或生理盐水。全身注射后，立即将大鼠置于保持在32摄氏度的电动跑步机上。以固定速度（10 m / min）进行运动，直到大鼠的核心温度达到41摄氏度。我们的结果表明，固定的运动负荷消失了温度和死亡率的降低，这是先前在自由移动大鼠中抑制DMH所见。因此，DMH中神经元介导的运动对于由MDMA引起的高热至关重要。 （C）2015 Elsevier B.V.保留所有权利。

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