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首页> 外文期刊>Brain research >Radiation-induced endothelial cell loss and reduction of the relative magnitude of the blood flow in the rat spinal cord
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Radiation-induced endothelial cell loss and reduction of the relative magnitude of the blood flow in the rat spinal cord

机译：辐射诱导的内皮细胞损失和大鼠脊髓血流相对量的减少

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The main purpose of the present study was to examine the time-dependent alterations in the endothelial cell density that occur in the first 180 days after irradiation of the spinal cord and the functional role of these alterations in the spinal cord blood flow. An irradiated cervical spinal cord rat model (C2-T2 segment) was generated using a ^Co irradiator to deliver 30 Gy. A significant loss of forelimb motor function was observed 180 days post-irradiation. The number of neurons in the anterior hom of the spinal cord began to decrease significantly 3 days post-irradiation compared with normal controls, reaching the lowest number at 90 days post-irradiation. A significant reduction in the endothelial cell density was observed from 14 days post-irradiation in the white matter and from 3 days post-irradiation in the gray matter. The lowest endothelial cell density was reached at 30 days post-irradiation in the white matter and at 60 days post-irradiation in the gray matter. A significant reduction in the microvessel density was observed from 3 days post-irradiation in both the white matter and the gray matter. The lowest microvessel density was reached at 90 days post-irradiation in both the white matter and the gray matter. A significant reduction in the relative magnitude of spinal cord blood flow was observed from 21 days post-irradiation. The lowest relative magnitude of spinal cord blood flow was reached at 90 days post-irradiation. We did not find any evidence of demyelination. The results revealed that a single 30-Gy irradiation dose resulted in impaired forelimb motor function, a decreased number of neurons, and reduced endothelial cell density, microvessel density and relative magnitude of spinal cord blood flow. However, a 30-Gy single-dose irradiation was not sufficient to induce demyelination in the rat spinal cord.
机译：本研究的主要目的是研究在照射脊髓后的头180天发生的内皮细胞密度的时间依赖性变化，以及这些变化在脊髓血流中的功能作用。使用^ Co辐射器产生经辐照的颈脊髓大鼠模型（C2-T2区段）以递送30 Gy。辐照后180天观察到前肢运动功能明显丧失。与正常对照组相比，辐照后3天脊髓前中的神经元数量开始明显减少，在辐照后90天达到最低数量。从白质照射后14天和灰质照射后3天开始，内皮细胞密度显着降低。在白质照射后30天和灰质照射后60天达到最低的内皮细胞密度。从照射后3天开始，白质和灰质中的微血管密度均显着降低。照射后第90天，白质和灰质中的微血管密度均达到最低。从照射后21天开始，观察到脊髓血流的相对量显着降低。照射后90天达到最低的脊髓血流相对量。我们没有发现任何脱髓鞘的证据。结果表明，单次30-Gy照射剂量会导致前肢运动功能受损，神经元数量减少，内皮细胞密度，微血管密度和脊髓血流相对量降低。但是，单剂量30 Gy照射不足以诱导大鼠脊髓脱髓鞘。

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