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Anxiolytic-lifee effects of phytol: Possible involvement of GABAergic transmission

机译：植醇的抗焦虑作用：可能参与了GABA能传递

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Phytol, a branched chain unsaturated alcohol, is particularly interesting because it is an isolated compound from essential oils of different medicinal plants. The aim of this study was to evaluate the anxiolytic-lifee effects of phytol in animal models to clarify their possible action mechanism. After acute intraperitoneal treatment with phytol at doses of 25, 50 and 75 mg/kg behavioral models of open-field, elevated-plus-maze, rota-rod, light-dark, marble-burying and pentobarbital sleeping time tests were utilized. In open field test, phytol (25, 50 and 75 mg/kg) [p<0.01] increased the number of crossings and rearings. However, the number of groomings [p<0.01] was reduced. Likewise, the number of entries and the time spent in light space were increased [p<0.01] while the number of marble-burying was decreased [p<0.001], in elevated-plus-maze, light-dark and marble-burying tests, respectively. In motor activity test, phytol (75 mg/kg) impaired the rota-rod performance of mice [p<0.01]. In pentobarbital sleeping time test, phytol 75 mg/kg decreased for latency of sleeping and phytol (25, 50 and 75 mg/kg) increased the sleep time when compared to negative control [p<0.05]. All these effects were reversed by pre-treatment with flumazenil (2.5 mg/kg, i.p.), similarly to those observed with diazepam (2 mg/kg, i.p.; positive control) suggesting that the phytol presents mechanism of action by interaction with the GABAergic system. These findings suggest that acute administration of phytol exerts an anxiolytic-lifee effect on mice. Furthermore, suppose that phytol interacts with GABAA receptor, probably at the receptor subtypes that mediate benzodia-zepines effects, to produce sedative and anxiolytic activities.
机译：植物醇，一种支链不饱和醇，特别令人感兴趣，因为它是从不同药用植物的精油中分离出来的化合物。这项研究的目的是评估植醇在动物模型中的抗焦虑作用，以阐明其可能的作用机理。在以25、50和75 mg / kg剂量的植醇进行急性腹膜内治疗后，采用了开放场，高架迷宫，旋转杆，浅暗，大理石埋藏和戊巴比妥睡眠时间测试的行为模型。在露天试验中，植醇（25、50和75 mg / kg）[p <0.01]增加了杂交和饲养的次数。但是，修饰的次数减少了[p <0.01]。同样，在高架迷宫，浅暗和大理石掩埋试验中，增加的条目数量和在浅色空间中花费的时间增加[p <0.01]，而减少大理石掩埋的次数[p <0.001] ， 分别。在运动活动测试中，植醇（75 mg / kg）损害了小鼠的旋转棒性能[p <0.01]。在戊巴比妥睡眠时间试验中，与阴性对照相比，睡眠延迟的植醇降低了75 mg / kg，植醇（25、50和75 mg / kg）增加了睡眠时间[p <0.05]。通过用氟马西尼（2.5 mg / kg，腹膜内）预处理可以逆转所有这些作用，与地西epa（2 mg / kg，腹膜内;阳性对照）观察到的结果相似，表明该植物醇通过与GABAergic相互作用表现出作用机制。系统。这些发现表明，植醇的急性给药对小鼠具有抗焦虑作用。此外，假设植醇与GABAA受体相互作用，可能在介导苯并二氮杂ze类药物作用的受体亚型上产生镇静和抗焦虑活性。

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