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Functional interactions between dentate gyrus, striatum and anterior thalamic nuclei on spatial memory retrieval

机译：齿状回，纹状体和丘脑前核之间的功能相互作用在空间记忆检索中的作用

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The standard model of memory system consolidation supports the temporal reorganization of brain circuits underlying long-term memory storage, including interactions between the dorsal hippocampus and extra-hippocampal structures. In addition, several brain regions have been suggested to be involved in the retrieval of spatial memory. In particular, several authors reported a possible role of the ventral portion of the hippocampus together with the thalamus or the striatum in the persistence of this type of memory. Accordingly, the present study aimed to evaluate the contribution of different cortical and subcortical brain regions, and neural networks involved in spatial memory retrieval. For this purpose, we used cytochrome c oxidase quantitative histochemistry as a reliable method to measure brain oxidative metabolism. Animals were trained in a hidden platform task and tested for memory retention immediately after the last training session; one week after completing the task, they were also tested in a memory retrieval probe. Results showed that retrieval of the previously learned task was associated with increased levels of oxidative metabolism in the prefrontal cortex, the dorsal and ventral striatum, the anterodorsal thalamic nucleus and the dentate gyrus of the dorsal and ventral hippocampus. The analysis of functional interactions between brain regions suggest that the dorsal and ventral dentate gyrus could be involved in spatial memory retrieval. In addition, the results highlight the key role of the extended hippocampal system, thalamus and striatum in this process. Our study agrees with previous ones reporting interactions between the dorsal hippocampus and the prefrontal cortex during spatial memory retrieval. Furthermore, novel activation patterns of brain networks involving the aforementioned regions were found. These functional brain networks could underlie spatial memory retrieval evaluated in the Morris water maze task. (C) 2015 Elsevier B.V. All rights reserved.
机译：记忆系统整合的标准模型支持长期记忆存储基础的脑回路的时间重组，包括背侧海马与海马外结构之间的相互作用。另外，已经提出了几个大脑区域参与空间记忆的检索。特别是，一些作者报道了海马腹侧部分以及丘脑或纹状体在这种类型的记忆持久性中的可能作用。因此，本研究旨在评估不同皮层和皮层下大脑区域以及参与空间记忆检索的神经网络的贡献。为此，我们使用了细胞色素C氧化酶定量组织化学作为一种可靠的方法来测量大脑的氧化代谢。在最后一次训练之后，立即对动物进行了隐藏平台任务训练，并测试了记忆力;在完成任务一周后，还对它们进行了内存检索探针测试。结果表明，先前学习的任务的恢复与额叶前额叶，背侧和腹侧纹状体，丘脑前丘脑核以及背侧和腹侧海马的齿状回的氧化代谢水平升高有关。对大脑区域之间功能相互作用的分析表明，背齿和腹齿状回可能参与空间记忆的检索。此外，结果突出了扩展海马系统，丘脑和纹状体在此过程中的关键作用。我们的研究与以前的报道一致，后者报道了在空间记忆检索过程中海马背侧和前额叶皮层之间的相互作用。此外，发现了涉及上述区域的脑网络的新型激活模式。这些功能性大脑网络可以作为在Morris水迷宫任务中评估的空间记忆检索的基础。 （C）2015 Elsevier B.V.保留所有权利。

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