• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain research >Differential roles of medial prefrontal subregions in the regulation of drug seeking
【24h】

Differential roles of medial prefrontal subregions in the regulation of drug seeking

机译：内侧前额叶次区域在寻找药物的调控中的不同作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The prefrontal cortex plays an important role in shaping cognition and behavior. Many studies have shown that medial prefrontal cortex (mPFC) plays a key role in seeking, extinction, and reinstatement of cocaine seeking in rodent models of relapse. Subregions of mPFC appear to play distinct roles in these behaviors, such that the prelimbic cortex (PL) is proposed to drive cocaine seeking and the infralimbic cortex (IL) is proposed to suppress cocaine seeking after extinction. This dichotomy of mPFC function may be a general attribute, as similar dorsal ventral distinctions exist for expression vs. extinction of fear conditioning. However, other results indicate that the role of mPFC neurons in reward processing is more complex than a simple PL-seek vs. IL-extinguish dichotomy. Both PL and IL have been shown to drive and inhibit drug seeking (and other types of behaviors) depending on a range of factors including the behavioral context, the drug-history of the animal, and the type of drug investigated. This heterogeneity of findings may reflect multiple subcircuits within each of these PFC areas supporting unique functions. It may also reflect the fact that the mPFC plays a multifaceted role in shaping cognition and behavior, including those overlapping with cocaine seeking and extinction. Here we discuss research leading to the hypothesis that dorsal and ventral mPFC differentially control drug seeking and extinction. We also present recent results calling the absolute nature of a PL vs. IL dichotomy into question. Finally, we consider alternate functions for mPFC that correspond less to response execution and inhibition and instead incorporate the complex cognitive behavior for which the mPFC is broadly appreciated.
机译：前额叶皮层在塑造认知和行为中起重要作用。许多研究表明，在啮齿类动物复发模型中，内侧前额叶皮层（mPFC）在寻找，消灭和恢复可卡因的寻找中起着关键作用。 mPFC的子区域在这些行为中似乎起着不同的作用，因此提出了前缘皮质（PL）来驱动可卡因的寻找，而提议下边缘皮质（IL）来抑制灭绝后的可卡因。 mPFC功能的这种二分法可能是一个普遍属性，因为恐惧表达的表达与消退存在相似的背腹侧区别。但是，其他结果表明，mPFC神经元在奖励过程中的作用比简单的PL寻求与IL消灭二分法更为复杂。已显示PL和IL均可根据一系列因素（包括行为背景，动物的药物史以及所研究的药物类型）来驱动和抑制药物寻找（以及其他类型的行为）。结果的这种异质性可能反映了这些支持独特功能的PFC区域中每个区域内的多个子电路。这也可能反映了一个事实，即mPFC在塑造认知和行为中起着多方面的作用，包括那些与可卡因寻求和消亡重叠的行为。在这里，我们讨论导致背侧和腹侧mPFC差异控制药物寻找和消灭的假说的研究。我们还提出了最近的结果，使PL与IL二分法的绝对性质受到质疑。最后，我们考虑了mPFC的替代功能，这些功能与响应执行和抑制的对应性较小，而是包含了mPFC广受赞赏的复杂认知行为。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号