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Corticostriatal BDNF and alcohol addiction

机译：皮质上皮BDNF与酒精成瘾

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Growth factors, long studied for their involvement in neuronal development and plasticity, also regulate responses to drugs of abuse, including alcohol. This review details the intricate interaction between the Brain-Derived Neurotrophic Factor (BDNF) and alcohol, and provides evidence to suggest that corticostriatal BDNF signaling acts to keep alcohol drinking in moderation. Specifically, we describe studies in rodent models suggesting that moderate consumption of alcohol increases BDNF levels in the dorsal striatum, which in turn act to suppress alcohol intake by activating a Mitogen-Activated Protein Kinase (MAPK)-dependent genomic mechanism. We further provide data to suggest that alcohol intake levels escalate when the endogenous corticostriatal BDNF pathway becomes dysregulated. Finally, we summarize recent studies suggesting that specific microRNAs targeting BDNF mRNA in the medial prefrontal cortex (mPFC) regulate the breakdown of the protective corticostriatal BDNF pathway.
机译：长期研究生长因子参与神经元发育和可塑性的生长因子，也调节了对滥用药物（包括酒精）的反应。这篇综述详细介绍了脑源性神经营养因子（BDNF）与酒精之间的复杂相互作用，并提供了证据表明皮质口骨BDNF信号传导可保持适度饮酒。具体而言，我们描述了在啮齿动物模型中的研究，这些研究表明适度饮酒会增加背侧纹状体中的BDNF水平，进而通过激活促分裂原活化的蛋白激酶（MAPK）依赖性基因组机制来抑制饮酒。我们进一步提供的数据表明，当内源性皮质口BDNF通路失调时，酒精摄入量会逐步增加。最后，我们总结了最近的研究，这些结果表明，靶向内侧前额叶皮层（mPFC）中的BDNF mRNA的特定microRNA调节了保护性皮质上皮BDNF途径的破坏。

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