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Medication safety during pregnancy

机译:孕期用药安全

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A recent American Academy of Neurology guideline on the management of epilepsy during pregnancy recommends avoiding polypharmacy as well as monotherapy with valproate.4 Use of multiple antiepileptic drugs (AEDs) during pregnancy is associated with an increased risk of major congenital anomalies.5 Valproate, an older AED, has been linked to an increased risk of neural tube defects and facial clefts.5'6 Teratogenicity data are becoming available for lamotrigine and levetiracetam, 2 commonly used newer AEDs.
机译:美国神经病学会最近关于妊娠期癫痫治疗的指南建议避免使用多药联用以及丙戊酸单药治疗。4妊娠期间使用多种抗癫痫药(AED)与重大先天性异常风险增加相关。5丙戊酸盐,一种较老的AED与神经管缺损和面部裂口的风险增加有关。5'6拉莫三嗪和左乙拉西坦这两种常用的较新的AED的致畸性数据越来越多。

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