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Euploid Single-Embryo Transfer:The New IVF Paradigm

机译：整倍体单胚胎移植：新的IVF范式

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Kathy is a 39-year-old G1P0010 with 2 years of unexplained infertility after a spontaneous miscarriage. After 3 cycles of injectable gonadotropins with timed intrauterine insemination (IUI) she progressed to treatment with in vitro fertilization (IVF). In her first cycle, she produced 4 blastocysts and the 2 of the highest quality were transferred. She was discharged to her obstetrician at 9 weeks' gestation with a twin intrauterine pregnancy. At 20 weeks' gestation, she had preterm contractions and precipitously delivered nonviable twins. She subsequently had a frozen single-embryo transfer (SET) that resulted in a negative pregnancy test and a second frozen SET, which resulted in a clinical miscarriage. The fetus was found to have trisomy 16 on cyto-genetic analysis. Kathy would like to undergo another IVF cycle. How should she be managed?
机译：凯西（Kathy）是39岁的G1P0010，自然流产后有2年无法解释的不育。经过3个周期的定时子宫内授精（IUI）注射促性腺激素后，她开始接受体外受精（IVF）治疗。在她的第一个周期中，她产生了4个胚泡，并转移了2个质量最高的胚泡。怀孕9周时，她因双胞胎妊娠而出院。妊娠20周时，她早产并突然分娩了无法存活的双胞胎。随后，她进行了冷冻的单胎移植（SET），导致妊娠试验阴性，而第二次冷冻的SET又导致了临床流产。在细胞遗传学分析中发现胎儿具有16三体性。凯西（Kathy）想再经历一次试管婴儿周期。应该如何管理她？

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