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Where the Rubber Meets the Road:Putative Applications of CT-MSCs in Models of Disease

机译：橡胶在哪里上路：CT-MSC在疾病模型中的潜在应用

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Historically, the clinical utility of CB was first established in sibling transplants, then allogeneic transplants and now great effort is underway to establish the utility of autologous CBSCs in acquired diseases. Unlike CBSCs, which differentiate into blood and immune-forming cells, the newborn's CT-MSCs have been shown in numerous independent studies to have the capacity to differentiate into bone39, nerve40, muscle41, and endocrine42 phenotypes, regulate immune responses43, and functionally repair or reconstitute relevant animal models of disease44. As will be discussed later, these and other studies using alternative sources of MSCs would indicate that the administration of autologous MSCs, alone or in combination with CBSCs for acquired diseases, may be highly beneficial in any number of indications.
机译：从历史上看，CB的临床效用首先是在同胞移植中确立，然后在同种异体移植中进行，现在正在努力建立自体CBSC在获得性疾病中的效用。与CBSC可以分化为血液和免疫形成细胞不同，新生儿的CT-MSC已在众多独立研究中显示出具有分化为骨骼39，神经40，肌肉41和内分泌42表型，调节免疫应答43以及功能修复或重建疾病的相关动物模型44。如将在后面讨论的，这些和其他使用MSC替代来源的研究将表明，对于获得性疾病，单独或与CBSC联合使用自体MSC在许多适应症中可能都是非常有益的。

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