Coexistence of Hydrogen-Bonded Loop and Extended Tetrapeptide Conformations

Valentina Cervetto; Rolf Pfister; Christoph Kolano

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Coexistence of Hydrogen-Bonded Loop and Extended Tetrapeptide Conformations

机译：氢键环和扩展的四肽构象共存

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The conformations of a protected tetrathiopeptide have been analysed by isotope labelling and two-dimensional infrared spectroscopy(2D-IR).It has been found that Boc-Ala-Gly(=S)-Ala-Aib-OMe in acetonitrile,as well as its oxopeptide analogue,can adopt a hydrogen-bonded loop confor- mation in coexistence with less restricted structures.The two types of conformations interconvert too quickly to be resolved on the nuclear magnetic resonance(NMR)timescale,but give rise to different cross peaks in two-dimensional infrared spectra.The hydrogen bond between the Boc terminal group and the amide proton of Aib can be broken by photoisomerisation of the thioamide bond.

机译：通过同位素标记和二维红外光谱（2D-IR）分析了被保护的四硫肽的构象。发现乙腈中的Boc-Ala-Gly（= S）-Ala-Aib-OMe以及它的氧肽类似物可以采用氢键结合的环状构象，并具有较少受限制的结构。两种构象相互转换太快，无法在核磁共振（NMR）时标上解析，但会导致不同的交叉峰。二维红外光谱.Aib的Boc末端基团与酰胺质子之间的氢键可通过硫酰胺键的光异构化而断裂。

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《Chemistry: A European journal》 |2007年第32期|共8页
作者
Valentina Cervetto; Rolf Pfister; Christoph Kolano;
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正文语种 eng
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conformation analysis; hydrogen bonds; NMR spectroscopy; peptides; photoisomerization;

机译：构象分析氢键NMR光谱肽光异构化;

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Coexistence of Hydrogen-Bonded Loop and Extended Tetrapeptide Conformations

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