An enantioselective approach to 2,3-disubstituted indolines through consecutive Br?nsted acid/Pd-complex-promoted tandem reactions

Duan Y.; Chen M.-W.; Ye Z.-S.; Wang D.-S.; Chen Q.-A.; Zhou Y.-G.

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An enantioselective approach to 2,3-disubstituted indolines through consecutive Br?nsted acid/Pd-complex-promoted tandem reactions

机译：通过连续的布朗斯台德酸/钯络合物促进的串联反应对2,3-二取代的二氢吲哚进行对映选择性的方法

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In tandem: A divergent and enantioselective approach to 2,3-disubstituted indolines was developed through consecutive Br?nsted acid/Pd-complex- promoted tandem reactions from simple 2-substituted indoles and aldehydes in one operation to give up to 98 % ee (see scheme; R~1=H, F, or Me; R ~2=alkyl; R~3=aryl or alkyl). Three Br?nsted acid promoted steps and two Pd-catalyzed hydrogenation steps were involved in this process.

机译：串联：通过一次简单的2-取代的吲哚和醛类的连续布朗斯台德酸/钯-络合物促进的串联反应，开发了一种对2,3-二取代的二氢吲哚的发散和对映选择性的方法，使ee高达98％（参见方案; R〜1 ＝ H，F或Me; R〜2 ＝烷基; R〜3 ＝芳基或烷基）。该过程涉及三个布朗斯台德酸促进步骤和两个钯催化的氢化步骤。

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《Chemistry: A European journal》 |2011年第26期|共5页
作者
Duan Y.; Chen M.-W.; Ye Z.-S.; Wang D.-S.; Chen Q.-A.; Zhou Y.-G.;
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正文语种 eng
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asymmetric catalysis; Br?nsted acid; hydrogenation; palladium; tandem reaction;

机译：不对称催化;布朗斯台德酸;加氢;钯;串联反应;

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1. An Enantioselective Approach to 2,3-Disubstituted Indolines through Consecutive Br?nsted Acid/Pd-Complex-Promoted Tandem Reactions [J] . Ying Duan Mu-Wang Chen Zhi-Shi Ye Duo-Sheng Wang Qing-An Chen Prof. Yong-Gui Zhou Chemistry - A European Journal . 2011,第26期

机译：通过连续布朗斯台德酸/钯络合物促进的串联反应对2,3-二取代的吲哚进行对映选择性的方法
2. Highly regioselective synthesis of 2,3-disubstituted 2 H-1-benzopyrans: Br?nsted acid catalyzed [4+2] cycloaddition reaction with a variety of arylalkynes via ortho-quinone methides [J] . Kenta Tanaka, Mayumi Sukekawa, Yosuke Shigematsu, Tetrahedron . 2017,第45期

机译：高度接收性合成2,3-二取代的2 H -1-苯并吡喃：Br？Nsted酸催化[4 + 2]环加成反应通过 ortho -quinone methares
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4. Catalytic Enantioselective Synthesisof a,a-Disubstituted Amino Acids: The StreckerReaction of Ketimines Using Chiral Poly-GadoliniumComplexes [C] . Masakatsu Shibasaki, Motomu Kanai ACS symposium asymmetric synthesis and application of α-amino acids . 2009

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机译：第1章：第1部分：从环碳四取代的醛制备3,3-二取代的氧吲哚的独特方法：全合成（ - ） - Coerularcine和（ - ） - Coxspirolactam A，第1章：第2部分：BR的合成范围：NSTED 酸催化反应o
6. Enantioselective Synthesis of αα-Disubstituted Lactones via a Chiral Brønsted Acid Catalyzed Intramolecular Cyclization [O] . Jennifer E. Wilent, Ghassan Qabaja, Kimberly S. Petersen -1

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机译：无金属苯环合成2,3-二取代萘的合成：布朗斯台德酸与2-（苯基乙炔基）苯甲醛和炔烃的反应

An enantioselective approach to 2,3-disubstituted indolines through consecutive Br?nsted acid/Pd-complex-promoted tandem reactions

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