Total synthesis of the cytotoxic 1,10-seco-eudesmanolides britannilactone and 1,6-O,O-diacetylbritannilactone

Merten J.; Wang Y.; Krause T.; Kataeva O.; Metz P.

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Total synthesis of the cytotoxic 1,10-seco-eudesmanolides britannilactone and 1,6-O,O-diacetylbritannilactone

机译：细胞毒性的1,10-seco-eudesmanolides britannilactone和1,6-O，O-diacetylbritannilactone的全合成

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摘要

A natural boost! The first synthetic access to the bioactive title compounds was achieved from the dienyl carboxylic acid 1 (see scheme), which in turn is readily available by using sultone chemistry. The enantioselective route developed here also confirms the relative and absolute configuration of these sesquiterpene lactones.

机译：自然的刺激！从二烯基羧酸1（参见方案）获得了对生物活性标题化合物的第一个合成途径，而后者又可以通过使用磺内酯化学方法轻松获得。这里开发的对映选择性途径也证实了这些倍半萜内酯的相对和绝对构型。

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《Chemistry: A European journal》 |2011年第12期|共3页
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Merten J.; Wang Y.; Krause T.; Kataeva O.; Metz P.;
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正文语种 eng
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antitumor agents; natural products; structure elucidation; terpenoids; total synthesis;

机译：抗肿瘤剂;天然产物;结构阐明;萜类化合物;全合成;

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1. Total Synthesis of the Cytotoxic 1,10-seco-Eudesmanolides Britannilactone and 1,6-O,O-Diacetylbritannilactone [J] . Dr. Jörn Merten Dr. Yuzhou Wang Dr. Tilo Krause, Dr. Olga Kataeva, Prof. Dr. Peter Metz Chemistry - A European Journal . 2011,第12期

机译：细胞毒性的1,10-seco-Eudesmanolides Britannilactone和1,6-O，O-Diacetylbritannilactone的全合成
2. A concise sultone route to highly oxygenated 1,10-seco-eudesmanolides - Enantioselective total synthesis of the antileukemic sesquiterpene lactones (-)-eriolanin and (-)-eriolangin [J] . Merten J, Hennig A, Schwab P, European journal of organic chemistry . 2006,第5期

机译：一条简明的磺内酯路线可实现高度氧化的1,10-seco-eudesmanolides-抗酮倍半萜内酯（-）-eriolanin和（-）-eriolangin的对映选择性全合成
3. Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates [J] . K. C. Nicolaou, Rohan D. Erande, Jun Yin, Journal of the American Chemical Society . 2018,第10期

机译：改进的Tubulysins的总合成以及对癌细胞具有高度有效细胞毒性的新型Tubulysins的设计，合成和生物学评估，这是潜在的抗体药物结合物
4. Progress toward the total synthesis of a cytotoxic norditerpene from Cephalotaxus sp. : the hainanolide (or harringtonolide)(Abstracts) [C] . Laurent Evanno, Bernard Bodo, Bastien Nay European Symposium on Organic Chemistry . 2007

机译：从头孢菌SP中朝着细胞毒性偏移的总合成的进展。：HainaNolide（或Harringtonolide）（摘要）
5. Total synthesis of microtubule stabilizing agent laulimalide and total syntheses of proposed structure of cytotoxic macrolide iriomoteolide-1a and -1b. [D] . Yuan, Hao. 2011

机译：微管稳定剂laulimalide的全合成和细胞毒性大环内酯iriomoteolide-1a和-1b拟议结构的总合成。
6. Natural Product Synthesis Special Feature: Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: The ester effect in acyclic 13-induction of deoxypropionates [O] . Stephen Hanessian, Vincent Mascitti, Simon Giroux 2004

机译：天然产物合成的特殊功能：细胞毒性环二肽（-）-doliculide的完全合成：无环13-脱氧丙酸酯的酯效应
7. -Novel indole-1-carbinols and 1,3'- Diindolylalkanes: synthesis and preliminary evaluation of their cytotoxicity in hepatocarcinoma cells: preparation of tris-oxazoles building blocks for the total synthesis of telomestatin [O] . Zedda Gloria 2012

机译：- 吲哚-1-甲醇和1,3'-二吲哚烷烃：合成和初步评估其在肝癌细胞中的细胞毒性：制备三恶唑结构单元用于全合成端粒抑素

Total synthesis of the cytotoxic 1,10-seco-eudesmanolides britannilactone and 1,6-O,O-diacetylbritannilactone

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