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Kinetic differentiation between homo- and alternating at DNA by sterically restricted phosphonium dyes

机译:空间受限制的DNA染料在DNA上的均相和交替之间的动力学区分

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摘要

Poly has a tracker: By sterically controlling monomer-dimer equilibria, novel dyes can kinetically differentiate between homo-AT and alternating AT-AT polynucleotides. In this way, the width and steric occupation of the DNA minor groove can be finely probed and can be easily assessed by induced CD signals (see figure).
机译:Poly具有跟踪器:通过在空间上控制单体-二聚体平衡,新型染料可以在动力学上区分同源AT和交替AT-AT多核苷酸。这样,可以精确探测DNA小沟的宽度和空间,并可以通过诱导的CD信号轻松评估(见图)。

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