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Nucleic acid functionalized graphene for biosensing

机译：核酸功能化石墨烯用于生物传感

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摘要

There is immense demand for complex nanoarchitectures based on graphene nanostructures in the fields of biosensing or nanoelectronics. DNA molecules represent the most versatile and programmable recognition element and can provide a unique massive parallel assembly strategy with graphene nanomaterials. Here we demonstrate a facile strategy for covalent linking of single stranded DNA (ssDNA) to graphene using carbodiimide chemistry and apply it to genosensing. Since graphenes can be prepared by different methods and can contain various oxygen containing groups, we thoroughly investigated the utility of four different chemically modified graphenes for functionalization by ssDNA. The materials were characterized in detail and the different DNA functionalized graphene platforms were then employed for the detection of DNA hybridization and DNA polymorphism by using impedimetric methods. We believe that our findings are very important for the development of novel devices that can be used as alternatives to classical techniques for sensitive and fast DNA analysis. In addition, covalent functionalization of graphene with ssDNA is expected to have broad implications, from biosensing to nanoelectronics and directed, DNA programmable, self-assembly.
机译：在生物传感或纳米电子领域，对基于石墨烯纳米结构的复杂纳米结构有巨大的需求。 DNA分子代表了最通用和可编程的识别元件，可以与石墨烯纳米材料一起提供独特的大规模平行组装策略。在这里，我们展示了一种使用碳二亚胺化学方法将单链DNA（ssDNA）与石墨烯共价连接的简便策略，并将其应用于基因检测。由于可以通过不同的方法制备石墨烯，并且可以包含各种含氧基团，因此我们彻底研究了四种不同的化学修饰石墨烯通过ssDNA进行官能化的用途。对该材料进行了详细表征，然后使用阻抗分析方法将不同的DNA功能化石墨烯平台用于DNA杂交和DNA多态性检测。我们相信，我们的发现对开发新型仪器非常重要，该仪器可以用作敏感和快速DNA分析的经典技术的替代品。此外，石墨烯与ssDNA的共价官能化有望产生广泛的影响，从生物传感到纳米电子学，再到定向的，DNA可编程的自组装。

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