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A cyclodextrin-based nanoassembly with bimodal photodynamic action

机译：具有双峰光动力作用的基于环糊精的纳米组件

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摘要

We have developed a supramolecular nanoassembly capable of inducing remarkable levels of cancer cell mortality through a bimodal action based on the simultaneous photogeneration of nitric oxide (NO) and singlet oxygen (~1O _2). This was achieved through the appropriate incorporation of an anionic porphyrin (as ~1O _2 photosensitizer) and of a tailored NO photodonor in different compartments of biocompatible nanoparticles based on cationic amphiphilic cyclodextrins. The combination of steady-state and time-resolved spectroscopic techniques showed the absence of significant intra- and interchromophoric interaction between the two photoactive centers embedded in the nanoparticles, with consequent preservation of their photodynamic properties. Photodelivery of NO and ~1O _2 from the nanoassembly on visible light excitation was unambiguously demonstrated by direct and real-time monitoring of these transient species through amperometric and time-resolved infrared luminescence measurements, respectively. The typical red fluorescence of the porphyrin units was essentially unaffected in the bichromophoric nanoassembly, allowing its localization in living cells. The convergence of the dual therapeutic action and the imaging capacities in one single structure makes this supramolecular architecture an appealing, multifunctional candidate for applications in biomedical research.
机译：我们已经开发了一种超分子纳米组件，该组件能够通过基于一氧化氮（NO）和单线态氧（〜1O _2）的同时光生化的双峰作用而诱导癌细胞死亡的显着水平。这是通过在基于阳离子两亲环糊精的生物相容性纳米颗粒的不同隔室中适当掺入阴离子卟啉（〜1O _2光敏剂）和量身定制的NO光供体来实现的。稳态和时间分辨光谱技术的结合表明，纳米颗粒中嵌入的两个光敏中心之间没有显着的内部和发色团间相互作用，因此保留了它们的光动力特性。通过分别通过安培和时间分辨红外发光测量直接和实时监测这些瞬态物种，明确证明了纳米组件在可见光激发下NO和〜1O _2的光传递。卟啉单元的典型红色荧光在双发色纳米组装体中基本不受影响，从而使其在活细胞中定位。在一个单一结构中双重治疗作用和成像能力的融合使这种超分子体系结构成为生物医学研究中有吸引力的多功能候选人。

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