An organocatalytic cascade strategy for the enantioselective construction of spirocyclopentane bioxindoles containing three contiguous stereocenters and two spiro quaternary centers

Sun W.; Zhu G.; Wu C.; Hong L.; Wang R.

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An organocatalytic cascade strategy for the enantioselective construction of spirocyclopentane bioxindoles containing three contiguous stereocenters and two spiro quaternary centers

机译：螺环戊烷生物辛酯对映选择性构建的有机催化级联策略，该对映体包含三个连续的立体中心和两个螺四元中心

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A rapid and efficient organocatalytic cascade sequence for the direct construction of spirocyclopentane bioxindoles has been carried out by using a chiral squaramide catalyst in the presence of a base. This process constitutes a powerful approach to the preparation of biologically important bispirooxindoles in high enantioselectivities (see scheme).

机译：通过在碱的存在下使用手性方酰胺催化剂已进行了直接构建螺环戊烷生物辛酯的快速有效的有机催化级联序列。该过程是制备具有高对映选择性的生物学上重要的双螺并恶灵的有效方法（参见方案）。

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《Chemistry: A European journal》 |2012年第22期|共5页
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Sun W.; Zhu G.; Wu C.; Hong L.; Wang R.;
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正文语种 eng
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cascade reactions; methyleneindolinone; organocatalysis; spiro compounds; squaramides;

机译：级联反应;亚甲基吲哚酮;有机催化;螺化合物;方酰胺;

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1. An organocatalytic cascade strategy for the enantioselective construction of spirocyclopentane bioxindoles containing three contiguous stereocenters and two spiro quaternary centers [J] . Sun W., Zhu G., Wu C., Chemistry: A European journal . 2012,第22期

机译：螺环戊烷生物辛酯对映选择性构建的有机催化级联策略，该对映体包含三个连续的立体中心和两个螺四元中心
2. An Organocatalytic Michael?Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters [J] . Wangsheng Sun, Liang Hong, Gongming Zhu, Organic letters . 2014,第2期

机译：螺环戊烷生物毒素的对映选择性构建的有机催化Michael？Michael级联反应：四个连续立体中心的控制
3. An Organocatalytic Michael?Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters [J] . Wangsheng Sun, Liang Hong, Gongming Zhu, Organic letters . 2014,第2期

机译：螺环戊烷生物毒素的对映选择性构建的有机催化Michael？Michael级联反应：四个连续立体中心的控制
4. Enantioselective Organocatalytic Construction of a Chiral Quaternary Carbon Center [C] . Yutaro Hanatani, Masaru Kondo, Shinobu Takizawa 日本化学会春季年会講演予稿集 . 2018

机译：手性四元碳中心的对映选择性有机催化结构
5. I. Studies on the organocatalytic formation of quaternary stereocenters. ii. Studies on the claisen rearrangement as a route to quaternary stereocenters. iii. Asymmetric synthesis of aldehydes bearing quaternary carbon centers via the decarboxylative asymmetric allylic alkylation. [D] . Alberch, Eduardo. 2013

机译：I.季铵立体中心的有机催化形成研究。 ii。关于克莱森重排作为四元立体中心路径的研究。 iii。通过脱羧不对称烯丙基烷基化反应不对称合成带有季碳中心的醛。
6. Asymmetric Synthesis of Spirocyclopentane OxindolesContaining Four Consecutive Stereocenters and Quaternary α-NitroEsters via Organocatalytic Enantioselective Michael–MichaelCascade Reactions [O] . PrakashD. Chaudhari, Bor-Cherng Hong, *, 2019

机译：螺环戊烷氧化吲哚的不对称合成包含四个连续的立体中心和第四级α-硝基通过有机催化对映选择性迈克尔-迈克尔酯级联反应
7. Organocatalytic Asymmetric Michael Addition of Pyrazolin-5-ones to Nitroolefins with Bifunctional Thiourea: Stereocontrolled Construction of Contiguous Quaternary and Tertiary Stereocenters [O] . Liao Yu-Hua, Chen Wen-Bing, Wu Zhi-Jun, 2010

机译：吡唑啉-5-酮对双官能硫脲的硝基烯烃的有机催化不对称迈克尔加成反应：连续四级和三级立体中心的立体控制结构。

An organocatalytic cascade strategy for the enantioselective construction of spirocyclopentane bioxindoles containing three contiguous stereocenters and two spiro quaternary centers

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