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首页> 外文期刊>Chemistry: A European journal >Synthesis of multifunctional Ag@Au@phenol formaldehyde resin particles loaded with folic acids for photothermal therapy
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Synthesis of multifunctional Ag@Au@phenol formaldehyde resin particles loaded with folic acids for photothermal therapy

机译：叶酸负载多功能Ag @ Au @酚醛树脂颗粒的光热治疗

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摘要

Multifunctional Ag@Au@ phenol formaldehyde resin (PFR) particles loaded with folic acids (FA) have been designed for killing tumor cells through photothermy conversion under the irradiation of near-infrared (NIR) light. Possessing the virtue of good fluorescence, low toxicity, and good targeting, the nanocomposite consists of an Ag core, an Au layer, a PFR shell, and folic acids on the PFR shell. The Ag@PFR core-shell structure can be prepared with a simple hydrothermal method after preheating. We then filled the PFR shell with a layer of Au by heating and modified the shell with polyelectrolyte to change its surface charge state. To capture tumor cells actively, FA molecules were attached onto the surface of the Ag@Au@PFR particles in the presence of 1-ethyl-3-(3-dimethly aminopropyl) carbodiimide (EDAC) and N-hydroxysuccinimide (NHS). Owing to the excellent property of Au NPs and Ag NPs as photothermal conversion agents, the Ag@Au@ PFR@FA particles can be utilized to kill tumor cells when exposed to NIR light. Locked and loaded: Multifunctional particles composed of an Ag core, an Au layer, and a phenol formaldehyde resin (PFR) shell were synthesized by a hydrothermal process with good reproducibility. Attachment of folic acids onto the PFR shell results in photothermal conversion particles, which exhibit high fluorescence, low toxicity, and effective targeting for the therapy of tumor cells (see figure).
机译：设计了负载叶酸（FA）的多功能Ag @ Au @酚醛树脂（PFR）颗粒，用于在近红外（NIR）光照射下通过光热转换杀死肿瘤细胞。纳米复合材料具有良好的荧光性，低毒性和良好的靶向性，它由Ag核，Au层，PFR壳和PFR壳上的叶酸组成。预热后，可以通过简单的水热法制备Ag @ PFR核-壳结构。然后，通过加热，我们在PFR外壳上填充了一层Au，并用聚电解质修饰了该外壳以改变其表面电荷状态。为了活跃地捕获肿瘤细胞，在1-乙基-3-（3-二甲基氨基丙基）碳二亚胺（EDAC）和N-羟基琥珀酰亚胺（NHS）的存在下，将FA分子附着到Ag @ Au @ PFR颗粒的表面。由于Au NPs和Ag NPs作为光热转化剂的优异性能，当暴露在近红外光下时，Ag @ Au @ PFR @ FA颗粒可用于杀死肿瘤细胞。锁定并加载：通过水热法合成了由银核，金层和酚醛树脂（PFR）壳组成的多功能颗粒。叶酸附着在PFR壳上会产生光热转化颗粒，该颗粒表现出高荧光性，低毒性和对肿瘤细胞治疗的有效靶向性（见图）。

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