Dual nucleophilic/electrophilic capture of in situ generated iminium ethers: Towards the synthesis of functionalized amide building blocks

Peng B.; ODonovan D.H.; Jurberg I.D.; Maulide N.

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Dual nucleophilic/electrophilic capture of in situ generated iminium ethers: Towards the synthesis of functionalized amide building blocks

机译：原位生成的亚胺醚的亲核/亲电双重捕获：走向功能化酰胺结构单元的合成

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Rearranging its feathers: The transformation of simple linear amides into a diverse range of branched, functionalized products by conversion to iminium esters is followed by sequential treatment with nucleophiles and electrophiles (see scheme). The method takes advantage of a novel Claisen rearrangement and the use of aromatic substrates greatly facilitates the formation of the intermediate iminium ether.

机译：重新整理羽毛：将简单的线性酰胺通过转化为亚氨基酯转化为各种支化的官能化产物，然后依次用亲核试剂和亲电试剂进行处理（参见方案）。该方法利用了新颖的克莱森重排的优势，并且芳族底物的使用极大地促进了中间亚胺醚的形成。

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《Chemistry: A European journal》 |2012年第51期|共5页
作者
Peng B.; ODonovan D.H.; Jurberg I.D.; Maulide N.;
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正文语种 eng
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关键词
amides; Claisen rearrangement; iminiums; keteniminium; rearrangement;

机译：酰胺;克莱森重排;亚胺;酮亚胺;重排;

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1. Dual nucleophilic/electrophilic capture of in situ generated iminium ethers: Towards the synthesis of functionalized amide building blocks [J] . Peng B., ODonovan D.H., Jurberg I.D., Chemistry: A European journal . 2012,第51期

机译：原位生成的亚胺醚的亲核/亲电双重捕获：走向功能化酰胺结构单元的合成
2. Contemporaneous Dual Catalysis by Coupling Highly Transient Nucleophilic and Electrophilic Intermediates Generated in Situ [J] . Barry M. Trost, Xinjun Luan Journal of the American Chemical Society . 2011,第6期

机译：同时通过原位产生的高瞬态亲核和亲电子中间体偶联双重催化
3. Synthesis of aromatic poly(ether amide amide ether ketone ketone)s by electrophilic Friedel-Crafts solution polycondensation [J] . Mingzhong Cai, Meihua Zhu, Jiangping Qian, Polymers for advanced technologies . 2011,第6期

机译：亲电Friedel-Crafts溶液缩聚反应合成芳族聚醚醚酰胺醚酮酮
4. Functionalization of Amide-Building Blocks with endo-Gd-N-Cluster-Fullerene for Synthesis of BioShuttle Conjugates as cell-specific intracellular MR-Contrast Agents [C] . Pipkorn R, Wiessler M, Dunsch L, European Conference on Chemistry for Life Sciences . 2011

机译：酰胺基层与富烯族胺的官能化，用于合成BioShuttle缀合物作为细胞特异性细胞内MR-造影剂
5. 1. Reduction of Tertiary Benzamides to Benzaldehydes by an in situ-Generated Schwartz Reagent (Cp2 Zirconium (Hydrogen)Chloride); Formal Synthesis of Lysergic Acid. 2. Ru-Catalyzed Amide-Directed Aryl Carbon-Hydrogen, Carbon-Nitrogen and Carbon-Oxygen Bond Functionalizations: C-B Formation, Carbon-Carbon Suzuki Cross Coupling and Hydrodemethoxylation [D] . Zhao, Yigang 2011

机译：1.通过原位生成的Schwartz试剂（Cp2氯化锆（氢）氯化物）将叔苄酰胺还原为苯甲醛；麦角酸的正式合成。 2. Ru催化的酰胺基芳烃碳氢，碳氮和碳氧键功能化：C-B形成，碳-碳铃木交叉偶联和加氢脱甲氧基化
6. Functionally Diverse Nucleophilic Trapping of Iminium Intermediates Generated Utilizing Visible Light [O] . David B. Freeman, Laura Furst, Allison G. Condie, -1

机译：亚胺鎓中间体的功能多样亲核捕集产生利用可见光
7. Nucleophilic Addition to Iminium Ethers in the Preparation of Functionalized N-Alkyl Heterocycles [O] . -1

机译：在官能化N-烷基杂环的制备中对亚尼米醚的亲核产物

Dual nucleophilic/electrophilic capture of in situ generated iminium ethers: Towards the synthesis of functionalized amide building blocks

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