Ratiometric fluorescent signaling of small molecule, environmentally sensitive dye conjugates for detecting single-base mutations in DNA

Wang C.-X.; Sato Y.; Kudo M.; Nishizawa S.; Teramae N.

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Ratiometric fluorescent signaling of small molecule, environmentally sensitive dye conjugates for detecting single-base mutations in DNA

机译：小分子，环境敏感的染料偶联物的比例荧光信号，用于检测DNA中的单碱基突变

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Bind it! A ratiometric fluorescent probe based on conjugation of a DNA-binding ligand with an environmentally sensitive dye to probe hydrophobic grooves of the DNA helix was developed. The resulting conjugate ATMND-DBD can bind to an orphan nucleobase opposite an abasic (AP) site with high selectivity and affinity for pyrimidine bases (see figure).

机译：绑定！基于DNA结合配体与环境敏感染料的缀合，以探测DNA螺旋的疏水性凹槽的比例荧光探针被开发出来。所得的缀合物ATMND-DBD可以与对嘧啶碱基的选择性和亲和力高的无碱基（AP）位点对立的孤核碱基结合（见图）。

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《Chemistry: A European journal》 |2012年第31期|共4页
作者
Wang C.-X.; Sato Y.; Kudo M.; Nishizawa S.; Teramae N.;
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正文语种 eng
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关键词
DNA recognition; fluorescent probes; ligand design; noncovalent interactions; nucleobases;

机译：DNA识别;荧光探针;配体设计;非共价相互作用;核碱基;

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1. Ratiometric fluorescent signaling of small molecule, environmentally sensitive dye conjugates for detecting single-base mutations in DNA [J] . Wang C.-X., Sato Y., Kudo M., Chemistry: A European journal . 2012,第31期

机译：小分子，环境敏感的染料偶联物的比例荧光信号，用于检测DNA中的单碱基突变
2. Sensitive immunoassay detection of multiple environmental chemicals on protein microarrays using DNA/dye conjugate as a fluorescent label [J] . Fan Z., Keum Y.S., Li Q.X., Journal of environmental monitoring: JEM . 2012,第5期

机译：使用DNA /染料偶联物作为荧光标记物对蛋白质微阵列上的多种环境化学品进行灵敏的免疫分析检测
3. A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment [J] . Wang Yue, Wang Xiaoyan, Zhang Li, Journal of Materials Chemistry, B. materials for biology and medicine . 2020,第5期

机译：用于检测肿瘤治疗期间内源生物信号分子超氧化物阴离子和生物成像的比例荧光探针
4. Detection of Cordycepin Using Indicator Displacement Assay of Cucurbit 7 Uril and Environmentally Sensitive Fluorescent Dyes [C] . Arinta Agnie Dewantari, Tanapat Nakprach, Jirarut Wongkongkatep Annual Basic Science International Conference . 2019

机译：使用葫芦（葫芦和环境敏感荧光染料）用指示剂位移测定检测蛹虫蛋白
5. Role of Dye-Doped Nanoparticles in Development of Polymer-Based Ratiometric Fluorescent Indicator to Detect Metal Ion Activity [D] . Parajuli, Bimal. 2018

机译：染料掺杂纳米颗粒在基于聚合物的比例荧光指示剂中检测金属离子活性的作用
6. One tube mutation detection using sensitive fluorescent dyeing of MutS protected DNA [O] . Pawe Sachadyn, Anna Stanisawska, Józef Kur 2000

机译：使用MutS保护的DNA的敏感荧光染色进行一管突变检测
7. A ratiometric fluorescent probe for detecting the endogenous biological signaling molecule superoxide anion and bioimaging during tumor treatment [O] . Yue Wang, Xiaoyan Wang, Li Zhang, 2020

机译：用于检测内源生物信号分子超氧化物阴离子和生物成像在肿瘤治疗过程中的比例荧光探针

Ratiometric fluorescent signaling of small molecule, environmentally sensitive dye conjugates for detecting single-base mutations in DNA

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