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Enantio- and chemoselective differentiation of protected α-amino acids and β-homoamino acids with a single copper(II) host

机译:具有单个铜(II)主体的受保护α-氨基酸和β-同氨基酸的对映和化学选择性分化

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摘要

The association between an achiral copper(II)-containing host 1 and chiral carboxylates has been expanded beyond previous studies to new chiral carboxylate guests, both α-amino acids and β-homoamino acids. The observed exciton-coupled circular dichroism (ECCD) signals for the enantiomers of each carboxylate were equal and opposite, and these signals differed in size and shape between the individual amino acids. Linear discriminant analysis (LDA) was applied as a statistical analysis technique to differentiate the amino acids, both enantioselectively and chemoselectively, giving the absolute configuration and identity of the amino acid. The identity of each of the α-amino acids and β-homoamino acids were determined independently by LDA, and then the two were considered together. Each of these analyses showed good differentiation of the amino acid guests with the use of only one host molecule.
机译:非手性含铜(II)的主体1和手性羧酸盐之间的联系已扩展到以前的研究之外,扩展到新的手性羧酸盐客体,α-氨基酸和β-均氨基酸。观察到的每个羧酸盐的对映异构体的激子偶联圆二色性(ECCD)信号相等且相反,并且这些信号在单个氨基酸之间的大小和形状不同。线性判别分析(LDA)被用作统计分析技术,以对映选择性和化学选择性区分氨基酸,从而给出了氨基酸的绝对构型和同一性。通过LDA独立地确定每个α-氨基酸和β-均氨基酸的身份,然后将两者一起考虑。这些分析中的每一个都表明仅使用一个宿主分子就能很好地区分氨基酸来宾。

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