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首页> 外文期刊>Chemistry: A European journal >A versatile and robust vesicle based on a photocleavable surfactant for two-photon-tuned release
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A versatile and robust vesicle based on a photocleavable surfactant for two-photon-tuned release

机译：基于光可裂解表面活性剂的多用途且坚固的囊泡，用于双光子调谐释放

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摘要

A small amphiphile that contains a coumarin unit and alkynyl groups, as a two-cleavable segment and polymerizable groups, respectively, was designed and synthesized. The amphiphile showed a critical aggregation concentration of about 4.6×10~(-5)M and formed a vesicle-type assembly. The formed vesicles were stabilized by insitu "click" polymerization without altering their morphology. Hydrophobic and hydrophilic guests can be encapsulated within the vesicle membrane and inside the aqueous core of the vesicle, respectively. The loaded guests can be released from the vesicle by using UV or near-IR stimuli, through splitting up the amphiphilic structure of the amphiphile. Distinguished dose-controlled photorelease of the polymeric vesicle is achieved with the maintenance of vesicular integrity, which makes the guest release dependent on the amount of cleavage of the amphiphilic structure during irradiation. This study provides a potential strategy for the development of versatile and stable drug-delivery systems that offer sustained and photo-triggered release.
机译：设计并合成了一个包含两分子香豆素单元和炔基的小两亲物，该两性可裂解的部分分别是可裂解的基团和可聚合的基团。两亲分子的临界聚集浓度约为4.6×10〜（-5）M，并形成囊泡型组装体。通过原位“点击”聚合来稳定形成的囊泡，而不会改变它们的形态。疏水和亲水客体可以分别包囊在囊膜内和囊的水核心内。通过分裂两亲物的两亲结构，可以通过使用紫外线或近红外刺激从囊泡中释放负载的客体。维持囊泡完整性可实现聚合物囊泡的剂量控制的光释放，这使得客体释放取决于辐照过程中两亲结构的裂解量。这项研究为开发多功能和稳定的药物递送系统（提供持续的和光触发的释放）提供了潜在的策略。

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