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首页> 外文期刊>Chemistry: A European journal >Artificial signal transduction with primary and secondary messengers
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Artificial signal transduction with primary and secondary messengers

机译：主，副信使的人工信号转导

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摘要

The complete, entirely artificial, signal-transduction process was realized with a pair of tailored transmembrane units that were equipped with receptor- and reactive sites at both amphiphilic ends. Thus, docking of the primary messenger, transmission of the signal, and release of the secondary messenger could all be imitated in a single experimental setup. The system imitates the signaling principle of receptor tyrosine kinases and employs bisphosphonate head-groups for oligoamine-recognition and a pair of thiol nucleophiles and pyridine disulfide tail-groups for intravesicle S _N2 displacement. This system operates in a unidirectional fashion, does not suffer from intervesicle competition, and is highly sensitive towards the lipid composition of the membrane and the nature of the primary messenger.
机译：完整的，完全人工的信号转导过程是通过一对定制的跨膜单元实现的，该单元在两亲性末端均具有受体和反应位点。因此，主信使的对接，信号的传输以及辅助信使的释放都可以在单个实验设置中被模仿。该系统模仿受体酪氨酸激酶的信号传导原理，并采用双膦酸酯头基团进行寡胺识别，并使用一对硫醇亲核试剂和吡啶二硫键尾基团进行囊内S _N2置换。该系统以单向方式操作，不受囊泡间竞争的影响，并且对膜的脂质组成和主要信使的性质高度敏感。

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