Engineering Cytochrome-Modified Silica Nanoparticles To Induce Programmed Cell Death

Wen-Yen Huang; Gemma-Louise Davies; Jason J. Davis

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Engineering Cytochrome-Modified Silica Nanoparticles To Induce Programmed Cell Death

机译：工程化细胞色素修饰的二氧化硅纳米粒子，以诱导程序性细胞死亡。

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A low native membrane permeability and ineffective access to the cellular cytosol, together with aggressive proteolytic degradation, often severely hampers the practical application of any therapeutic protein or antibody. Through engineering the charging profile of mesoporous silica nanoparticles, cellular uptake and subsequent subcellular distribution can be controlled. We show herein that programmed cell death can subsequently be induced across a population of cancer cells with remarkable efficacy on conjugating a specific caspase-cascade-activating cytochrome to such cytosol-accessing particles.

机译：低的天然膜通透性和对细胞质溶胶的无效访问以及激进的蛋白水解降解常常严重地阻碍了任何治疗性蛋白质或抗体的实际应用。通过设计中孔二氧化硅纳米粒子的电荷分布，可以控制细胞摄取和随后的亚细胞分布。我们在本文中显示，随后可在整个癌细胞群体中诱导程序性细胞死亡，所述细胞具有将特定的胱天蛋白酶级联激活细胞色素缀合至此类细胞质进入颗粒的显着功效。

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《Chemistry: A European journal》 |2013年第52期|共8页
作者
Wen-Yen Huang; Gemma-Louise Davies; Jason J. Davis;
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apoptosis; endosomal escape; nanomaterials; proteins; therapeutics;

机译：凋亡;内体逸出;纳米材料;蛋白质;治疗;

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1. Engineering Cytochrome-Modified Silica Nanoparticles To Induce Programmed Cell Death [J] . Wen-Yen Huang, Gemma-Louise Davies, Jason J. Davis Chemistry: A European journal . 2013,第52期

机译：工程化细胞色素修饰的二氧化硅纳米粒子，以诱导程序性细胞死亡。
2. PEG2000-DPSE-coated quercetin nanoparticles remarkably enhanced anticancer effects through induced programed cell death on C6 glioma cells [J] . WangG., WangJ., LuoJ., Journal of biomedical materials research, Part A . 2013,第11期

机译：PEG2000-DPSE涂层的槲皮素纳米颗粒通过诱导C6胶质瘤细胞程序性细胞死亡显着增强抗癌作用
3. Spontaneous Cancers, But Not Many Induced Ones in Animals, Resemble Semi-New Organisms that Possess a Unique Programmed Cell Death Mode Different from Apoptosis, Senescent Death, Necrosis and Stress-Induced Cell Death [J] . Journal of Cancer . 2018,第24期

机译：自发性癌症，但在动物中诱发的并不多，类似于半新生物，具有独特的程序性细胞死亡模式，不同于凋亡，衰老死亡，坏死和应激诱导的细胞死亡
4. p53-Induced ROS-accumulation induces programmed cell death in C6 glioma cells [C] . Wang Gang, Wang JunJie, Li BaoYuan, International Conference on Information Science, Electronics and Electrical Engineering . 2014

机译：p53诱导的ROS积累在C6胶质瘤细胞中诱导程序性细胞死亡
5. In vitro toxicity and oxidative stress induced by silica, cerium oxide, and zinc oxide nanoparticles in human lung epithelial cells. [D] . Lin, Weisheng. 2007

机译：二氧化硅，氧化铈和氧化锌纳米粒子在人肺上皮细胞中诱导的体外毒性和氧化应激。
6. Engineering Cytochrome-Modified Silica Nanoparticles To Induce Programmed Cell Death [O] . Wen-Yen Huang, Gemma-Louise Davies, Jason J. Davis -1

机译：工程改造细胞色素修饰的二氧化硅纳米颗粒以诱导程序性细胞死亡
7. Engineering cytochrome-modified silica nanoparticles to induce programmed cell death. [O] . Huang, WY, Davies, GL, Davis, JJ 2013

机译：工程化细胞色素修饰的二氧化硅纳米颗粒，以诱导程序性细胞死亡。

Engineering Cytochrome-Modified Silica Nanoparticles To Induce Programmed Cell Death

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