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首页> 外文期刊>Chemistry: A European journal >Photoinduced fluorescence activation and nitric oxide release with biocompatible polymer nanoparticles
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Photoinduced fluorescence activation and nitric oxide release with biocompatible polymer nanoparticles

机译：生物相容性聚合物纳米粒子的光诱导荧光活化和一氧化氮释放

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摘要

A viable strategy to encapsulate a fluorophore/photochrome dyad and a nitric oxide photodonor within supramolecular assemblies of a cyclodextrin-based polymer in water was developed. The two photoresponsive guests do not interact with each other within their supramolecular container and can be operated in parallel under optical control. Specifically, the dyad permits the reversible switching of fluorescence on a microsecond timescale for hundreds of cycles, and the photodonor enables the irreversible release of nitric oxide. Furthermore, these supramolecular assemblies cross the membrane of human melanoma cancer cells and transport their cargo in the cytosol. The fluorescence of one component allows the visualization of the labeled cells, and its switchable character could, in principle, be used to acquire super-resolution images, while the release of nitric oxide from the other induces significant cell mortality. Thus, our design logic for the construction of biocompatible nanoparticles with dual functionality might evolve into the realization of valuable photoresponsive probes for imaging and therapeutic applications. Cyclodextrins: Photoresponsive polymer nanoparticles encapsulate fluorophore/photochrome dyads and nitric oxide photodonors within their hydrophobic interior and transport their cargo across the membrane of living cells. The two guests can be used simultaneously within the macromolecular host to activate fluorescence and release nitric oxide under optical control (see scheme).
机译：开发了一种可行的策略，将荧光基团/光铬双性体和一氧化氮光供体封装在水中的环糊精基聚合物的超分子组装物中。两位光敏性宾客在其超分子容器内不会互相影响，可以在光学控制下并行操作。特别地，二分体允许在微秒的时间尺度上可逆地切换荧光数百个循环，而光供体使得一氧化氮的不可逆释放。此外，这些超分子装配体穿过人黑素瘤癌细胞的膜并在细胞质中运输它们的货物。一种成分的荧光使可视化标记的细胞，并且其可切换特性原则上可用于获取超分辨率图像，而另一种成分释放的一氧化氮则可引起明显的细胞死亡。因此，我们用于构建具有双重功能的生物相容性纳米粒子的设计逻辑可能会演变为实现用于成像和治疗应用的有价值的光敏探针。环糊精：光敏性聚合物纳米颗粒将荧光团/光敏染料二氧化氮和一氧化氮光供体封装在其疏水内部，并将其货物运输穿过活细胞的膜。可以在大分子宿主中同时使用两个来宾，以在荧光控制下激活荧光并释放一氧化氮（请参阅方案）。

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