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首页> 外文期刊>Chemistry: A European journal >Poly(acrylic acid)-modified Fe_3O_4 microspheres for magnetic-targeted and pH-triggered anticancer drug delivery
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Poly(acrylic acid)-modified Fe_3O_4 microspheres for magnetic-targeted and pH-triggered anticancer drug delivery

机译：聚（丙烯酸）修饰的Fe_3O_4微球用于磁靶向和pH触发的抗癌药物递送

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摘要

Monodisperse poly(acrylic acid)-modified Fe_3O_4 (PAA@Fe_3O_4) hybrid microspheres with dual responses (magnetic field and pH) were successfully fabricated. The PAA polymer was encapsulated into the inner cavity of Fe_3O_4 hollow spheres by a vacuum-casting route and photo-initiated polymerization. TEM images show that the samples consist of monodisperse porous spheres with a diameter around 200 nm. The Fe_3O_4 spheres, after modification with the PAA polymer, still possess enough space to hold guest molecules. We selected doxorubicin (DOX) as a model drug to investigate the drug loading and release behavior of as-prepared composites. The release of DOX molecules was strongly dependent on the pH value due to the unique property of PAA. The HeLa cell-uptake process of DOX-loaded PAA@Fe_3O_4 was observed by confocal laser scanning microscopy (CLSM). After being incubated with HeLa cells under magnet magnetically guided conditions, the cytotoxtic effects of DOX-loaded PAA@Fe_3O_4 increased. These results indicate that pH-responsive magnetic PAA@Fe_3O_4 spheres have the potential to be used as anticancer drug carriers. Dual response: Monodisperse poly(acrylic acid)-modified Fe_3O_4 (PAA@Fe _3O_4) hybrid microspheres with dual responses (magnetic field and pH) were successfully fabricated (see figure). The drug release behavior was strongly dependent on pH value due to the unique properties of PAA. Furthermore, doxorubicin (DOX)-loaded PAA@Fe_3O_4 composites show an enhanced magnetically guided anticancer effect.
机译：成功制备了具有双响应（磁场和pH值）的单分散聚丙烯酸改性Fe_3O_4（PAA @ Fe_3O_4）杂化微球。通过真空流延和光引发聚合将PAA聚合物封装在Fe_3O_4空心球的内腔中。 TEM图像显示样品由直径约200 nm的单分散多孔球组成。用PAA聚合物改性后，Fe_3O_4球仍具有足够的空间容纳客体分子。我们选择阿霉素（DOX）作为模型药物，以研究制备好的复合物的载药量和释放行为。由于PAA的独特特性，DOX分子的释放强烈依赖于pH值。通过共聚焦激光扫描显微镜（CLSM）观察了DOX负载的PAA @ Fe_3O_4的HeLa细胞摄取过程。在磁力引导的条件下与HeLa细胞孵育后，DOX负载的PAA @ Fe_3O_4的细胞毒性作用增强。这些结果表明，pH响应性磁性PAA @ Fe_3O_4球形具有用作抗癌药物载体的潜力。双重响应：成功制备了具有双重响应（磁场和pH）的单分散聚丙烯酸改性的Fe_3O_4（PAA @ Fe _3O_4）杂化微球（见图）。由于PAA的独特性质，药物释放行为强烈依赖于pH值。此外，负载阿霉素（DOX）的PAA @ Fe_3O_4复合材料显示出增强的磁导抗癌效果。

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