A gadolinium complex confined in silica nanoparticles as a highly efficient T_1/T_2 MRI contrast agent

Wartenberg N.; Fries P.; Raccurt O.; Guillermo A.; Imbert D.; Mazzanti M.

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A gadolinium complex confined in silica nanoparticles as a highly efficient T_1/T_2 MRI contrast agent

机译：作为高效T_1 / T_2 MRI造影剂的in复合物，被限制在二氧化硅纳米颗粒中

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摘要

Gd in silica: Noncovalent confinement of a monoaqua Gd chelate into biocompatible silica nanoparticles (NPs; see figure) by a sol-gel method affords a new example of nanosized contrast agents with very high per-Gd relaxivities. Such NPs provide a route to highly efficient multimodal contrast agents.

机译：二氧化硅中的Gd：通过溶胶-凝胶法将一水合Gd螯合物非共价限制在生物相容性二氧化硅纳米粒子（NP;见图）中，提供了具有很高的每Gd弛豫度的纳米级造影剂的新实例。这样的NP提供了通往高效多峰造影剂的途径。

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《Chemistry: A European journal》 |2013年第22期|共4页
作者
Wartenberg N.; Fries P.; Raccurt O.; Guillermo A.; Imbert D.; Mazzanti M.;
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正文语种 eng
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关键词
contrast agents; gadolinium; lanthanides; luminescence; nanoparticles;

机译：造影剂;ga;镧系元素;发光;纳米粒子;

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专利

1. A gadolinium complex confined in silica nanoparticles as a highly efficient T_1/T_2 MRI contrast agent [J] . Wartenberg N., Fries P., Raccurt O., Chemistry: A European journal . 2013,第22期

机译：作为高效T_1 / T_2 MRI造影剂的in复合物，被限制在二氧化硅纳米颗粒中
2. Mesoporous Silica-Coated Hollow Manganese Oxide Nanoparticles as Positive T_1 Contrast Agents for Labeling and MRI Tracking of Adipose-Derived Mesenchymal Stem Cells [J] . Taeho Kim, Eric Momin, Jonghoon Choi, Journal of the American Chemical Society . 2011,第9期

机译：介孔二氧化硅包覆的空心氧化锰纳米粒子作为T_1造影剂的阳性标记，用于脂肪来源的间充质干细胞的标记和MRI追踪
3. Mn~Ⅱ-containing coordination nanoparticles as highly efficient T_1 contrast agents for magnetic resonance imaging [J] . Gabriella Paul, Yoann Prado, Nada Dia, Chemical Communications . 2014,第51期

机译：含Mn〜Ⅱ的配位纳米颗粒作为磁共振成像的高效T_1造影剂
4. Tumor targetable high-field MRI T_1 contrast conjugates with Gd(Ⅲ)-chelate complexes and protein cage nanoparticles [C] . Hansol Kim, Seokha Jin, Hyukjun Choi, Society for Biomaterials annual meeting and exposition . 2019

机译：肿瘤靶向高场MRI T_1造影剂与Gd（Ⅲ）-螯合物和蛋白笼纳米颗粒的结合
5. Oxide-Free Gadolinium Nanoparticles as MRI Contrast Agents [D] . Ertas, Yavuz Nuri. 2017

机译：无氧化物Ga纳米粒子作为MRI造影剂
6. T1–T2 Dual-modal MRI contrast agents based on superparamagnetic iron oxide nanoparticles with surface attached gadolinium complexes [O] . Agnieszka Szpak, Sylwia Fiejdasz, Witold Prendota, -1

机译：基于超顺磁性氧化铁纳米粒子和表面nanoparticles复合物的T1-T2双模态MRI造影剂
7. Surface engineering of silica nanoparticles with a gadolinium–PCTA complex for efficient T1-weighted MRI contrast agents [O] . Paul Mathieu, Marie Chalet, Marie Myriam Clain, 2020

机译：用钆-PCTA复合物的二氧化硅纳米粒子的表面工程，用于高效的T1加权MRI造影剂

A gadolinium complex confined in silica nanoparticles as a highly efficient T_1/T_2 MRI contrast agent

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