Gold(I)-catalyzed 6-endo-dig hydrative cyclization of an alkyne-tethered ynamide: Access to 1,6-dihydropyridin-2(3H)ones

Ghosh N.; Nayak S.; Sahoo A.K.

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Gold(I)-catalyzed 6-endo-dig hydrative cyclization of an alkyne-tethered ynamide: Access to 1,6-dihydropyridin-2(3H)ones

机译：金（I）催化的炔烃拴住的酰胺的6-内-挖水合环化：获得1,6-二氢吡啶-2（3H）酮

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Hydrate your chemistry! Hydrative cyclization of 5-yne-ynamides in the presence of Echavarren's catalyst and p-toluenesulphonic acid (PTSA)×H_2O at room temperature affords an array of 1,6-dihydropyridin-2(3H)one derivatives. Isomerization, epoxidation, and hydrogenation of the double bond and insertion of an extended π-conjugate system into the pyridinone skeleton have been successfully accomplished (see scheme; Ts=tosyl).

机译：补充您的化学物质！在室温下，在Echavarren's催化剂和对甲苯磺酸（PTSA）×H_2O的存在下，对5-炔基酰胺进行水合环化反应，得到了一系列的1,6-二氢吡啶-2（3H）one衍生物。已成功完成双键的异构化，环氧化和加氢反应，以及将扩展的π共轭体系插入吡啶酮骨架中（参见方案; Ts =甲苯磺酰基）。

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《Chemistry: A European journal》 |2013年第29期|共6页
作者
Ghosh N.; Nayak S.; Sahoo A.K.;
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正文语种 eng
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gold catalysis; heterocycles; hydrative cyclization; pyridinones; yne-ynamides;

机译：金催化;杂环;水合环化;吡啶酮;炔炔;

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1. Gold(I)-catalyzed 6-endo-dig hydrative cyclization of an alkyne-tethered ynamide: Access to 1,6-dihydropyridin-2(3H)ones [J] . Ghosh N., Nayak S., Sahoo A.K. Chemistry: A European journal . 2013,第29期

机译：金（I）催化的炔烃拴住的酰胺的6-内-挖水合环化：获得1,6-二氢吡啶-2（3H）酮
2. Gold-Catalyzed [4+2]- and [3+3]-Annulations of Ynamides with 1-Yn-3-ols to Access Six-Membered Carbocycles and Oxacycles via Three Distinct Cyclizations [J] . Giri Sovan Sundar, Liu Rai-Shung Advanced synthesis & catalysis . 2017,第19期

机译：金催化[4 + 2] - 和[3 + 3]与1 yn-3-Ols的玛基碳化物，通过三个不同的环化进入六元碳缩放和氧化梗
3. Gold-Catalyzed [4+2]- and [3+3]-Annulations of Ynamides with 1-Yn-3-ols to Access Six-Membered Carbocycles and Oxacycles via Three Distinct Cyclizations [J] . Giri Sovan Sundar, Liu Rai-Shung Advanced synthesis & catalysis . 2017,第19期

机译：金催化[4 + 2] - 和[3 + 3]与1 yn-3-Ols的玛基碳化物，通过三个不同的环化进入六元碳缩放和氧化梗
4. Probing Gold-Catalyzed Alkyne Hydration Reaction by Mass Spectrometry: Evidence for Dinuclear Gold Intermediates [C] . Mei Lu, Yijin Su, Yumeng Xi, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：质谱法探测金催化的炔烃水合反应：二核金中间体的证据
5. I. Total synthesis of acortatarin A using a palladium-catalyzed spiroketalization methodology II. Tandem gold-catalyzed cyclization/Diels-Alder reactions. [D] . Borrero, Nicholas V. 2012

机译：I.使用钯催化的螺酮缩合方法全合成角蛋白A。串联金催化的环化/ Diels-Alder反应。
6. One-pot Diels–Alder cycloaddition/gold(I)-catalyzed 6-endo-dig cyclization for the synthesis of the complex bicyclo3.3.1alkenone framework [O] . Boubacar Sow, Gabriel Bellavance, Francis Barabé, 2011

机译：一锅Diels–Alder环加成/金（I）催化的6-endo-dig环化反应合成复杂的双环3.3.1烯酮骨架
7. Enantioselective Gold(I)-Catalyzed Hydrative Cyclizations of NPropargyl-ynamides into 3,6-Dihydropyridinones [O] . -1

机译：对映选择性的金（I） - 催化NProgargyl-ynamides的水合酸洗成3,6-二氢吡啶酮

Gold(I)-catalyzed 6-endo-dig hydrative cyclization of an alkyne-tethered ynamide: Access to 1,6-dihydropyridin-2(3H)ones

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