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首页> 外文期刊>Chemistry: A European journal >Iron metal-organic frameworks MIL-88B and NH_2-MIL-88B for the loading and delivery of the gasotransmitter carbon monoxide
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Iron metal-organic frameworks MIL-88B and NH_2-MIL-88B for the loading and delivery of the gasotransmitter carbon monoxide

机译：铁金属有机骨架MIL-88B和NH_2-MIL-88B，用于气体传输一氧化碳的装载和输送

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摘要

Crystals of MIL-88B-Fe and NH_2-MIL-88B-Fe were prepared by a new rapid microwave-assisted solvothermal method. High-purity, spindle-shaped crystals of MIL-88B-Fe with a length of about 2 μm and a diameter of 1 μm and needle-shaped crystals of NH_2-MIL-88B-Fe with a length of about 1.5 μm and a diameter of 300 nm were produced with uniform size and excellent crystallinity. The possibility to reduce the as-prepared frameworks and the chemical capture of carbon monoxide in these materials was studied by in situ ultrahigh vacuum Fourier-transform infrared (UHV-FTIR) spectroscopy and M?ssbauer spectroscopy. CO binding occurs to unsaturated coordination sites (CUS). The release of CO from the as-prepared materials was studied by a myoglobin assay in physiological buffer. The release of CO from crystals of MIL-88B-Fe with t_(1/2)=38 min and from crystals of NH _2-MIL-88B-Fe with t_(1/2)=76 min were found to be controlled by the degradation of the MIL materials under physiological conditions. These MIL-88B-Fe and NH_2-MIL-88B-Fe materials show good biocompatibility and have the potential to be used in pharmacological and therapeutic applications as carriers and delivery vehicles for the gasotransmitter carbon monoxide.
机译：采用新型的快速微波辅助溶剂热法制备了MIL-88B-Fe和NH_2-MIL-88B-Fe晶体。长度约为2μm，直径为1μm的MIL-88B-Fe高纯度纺锤形晶体以及长度约为1.5μm的直径为NH_2-MIL-88B-Fe的针状晶体制得的300nm的纳米颗粒具有均匀的尺寸和优异的结晶度。通过原位超高真空傅里叶变换红外（UHV-FTIR）光谱和Msssbauer光谱研究了在这些材料中减少所制备的骨架和一氧化碳化学捕获的可能性。 CO结合到不饱和配位位点（CUS）。通过在生理缓冲液中的肌红蛋白测定研究了从制备好的材料中释放出的CO。发现从t_（1/2）= 38 min的MIL-88B-Fe晶体和t_（1/2）= 76 min的NH _2-MIL-88B-Fe晶体中释放CO受以下控制：生理条件下MIL材料的降解。这些MIL-88B-Fe和NH_2-MIL-88B-Fe材料显示出良好的生物相容性，并有可能在药物和治疗应用中用作气体传输一氧化碳的载体和传输载体。

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